Tezislər / Theses

 
 

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THE 3
rd
 INTERNATIONAL SCIENTIFIC CONFERENCES OF STUDENTS AND YOUNG RESEARCHERS 
dedicated to the 99
th
anniversary of the National Leader of Azerbaijan Heydar Aliyev
402
CINNAMALDEHYDE BASED NEW SCHIFF BASES AS 
EFFECTIVE ANTIMICROBIALS 
Fargana Alizadeh
1,2
, Alakbar Huseynzada
2,3
, Ulviyya Hasanova
2,3
,
Ulviyya Yolcuyeva
1
, Vaqif Abbasov
1
 
1
Petrochemical processes of Institute
2
Azerbaijan State University of Oil and Industry
3
Baku State University
Baku, Azerbaijan 
[e-mail] 
Supervisor: Alakbar Huseynzada 
Keywords: 
Schiff bases, cinnamaldehyde derivatives, antimicrobial activity 
Since their first synthesis by Hugo Schiff in 1864, Schiff bases containing 
imine or azomethine functional groups have been proven to be a special 
class of organic compounds due to their wide applications in such important 
fields as chemistry, biology, medicine and pharmaceutics
3
. Schiff bases are 
common organic structures that can be easily synthesized through a one-
step synthetic procedure via condensation of aldehydes or ketones with 
aromatic or aliphatic amines. For years, Schiff bases have been widely used 
as toxic and essential metal sensors, as molecular memory devices and 
switches, in non-linear devices, as catalysts in electrochemistry and 
magnetochemistry, in asymmetric synthesis and epoxidation, in biomedical 
applications and they have also been used extensively as ligands in 
coordination chemistry. Moreover, Schiff bases exhibit many different biological 
activities, including antibacterial, antifungal, anticancer, antituberculosis, 
herbicidal, anti-HIV, antimalarial, antiproliferative, antiviral and antipyretic 
properties
2
.
From the other side, cinnamaldehyde, a major constituent of cinnamon 
oil, is an aromatic compound with a benzene ring and an aldehyde group 
attached to an unsaturated C=C bond at both ends. It was found that it has 
a wide variety of bioactive properties. Studies on cinnamaldehyde have shown 
that it exhibits a broad range of biological activities, such as anticancer, 
antibacterial, antioxidant, anti-inflammatory, antitumor, antifungal, mutagenic, 
analgesic and antidiabetic properties
1
.
Taking into account all mentioned, novel azomethines on the basis of o-
methoxycinnamaldehyde and polyamines such as tris(2-aminoethyl)amine 
and 2,2′-(ethylenedioxy)bis(ethylamine) were synthesized. The structures of 
the synthesized Schiff bases were investigated by 
1
H and 
13
C NMR and mass 
spectroscopy methods as well as elemental analysis. Taking into account 
above mentioned broad spectrum of biological activities, the next step of 
investigations was the determination of biological activities of newly 
synthesized Schiff bases. The biological activity of synthesized azomethines 

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