THE 3 rd INTERNATIONAL SCIENTIFIC CONFERENCES OF STUDENTS AND YOUNG RESEARCHERS dedicated to the 99
th
anniversary of the National Leader of Azerbaijan Heydar Aliyev
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SYNTHESIS OF NEW 3,5-DICHLOROSALICYLALDEHYDE BASED AZOMETHINES AND THEIR MODIFICATION WITH SILVER NANOPARTICLES S.I. Ismayilova 1,2 , R.N. Ganbarova 2 , A.E. Huseynzada 1,2 , N.A. Quliyeva 2 , U.A. Hasanova 1,2 , 1 Baku State University 2 Azerbaijan State Oil and İ ndustry University Baku, Azerbaijan samiraismayilova249@gmail.com Supervisor: Alakbar Huseynzada Keywords: Schiff bases, salicylic aldehyde, Ag nanoparticles.
Schiff bases or azomethines are one of the most significant synthons in
organic synthesis and they are formed by the condensation of carbonyl
compounds with amines, resulting in the production of an imine bond. They
are of interest to pharmacists not only because of their synthetic importance
but also because they exhibit a wide range of biological capabilities. Various
studies have demonstrated that these remarkable chemicals have antibacterial,
antiviral, antifungal, anti-hıv, antidiabetic, anticancer and other properties.
These remarkable chemicals, in particular salicylaldehyde derivatives, have
such a wide range of functions that they could be used to develop new drugs.
From the other point, due to the high activity and easy cell penetration
properties, various nanoparticles either independently or inside ensembles
are frequently used in drug design. Among them, silver nanoparticles are
used to increase the biological activity of the targeted drug due to their
immense and broad spectrum of biological activity, in particular antiviral,
antibacterial, anticancer, anti-HIV, antileishmanial and so on.[4-5]
Taking into account all above mentioned, synthesis of new azomethines
on the basis of salicylaldehyde derivative and their modification with silver
nanoparticles were performed. As aldehyde component was used 3,5-
dichlorosalicylaldehyde, whereas 2,2′,2′′-nitrilotriethylamine and 1,8-
diamino-3,6-dioxaoctane were used as an amine scaffold.
