MALIGNANT AND BENIGN CAUSES
Malignant Causes
The most common malignancy associated with
SVCS is lung cancer, followed by lymphomas and
metastatic tumors to the mediastinum (Table 1).
Lung tumors.
Approximately 5% to 15% of patients
with bronchogenic carcinoma develop SVCS. The syn-
drome is four times more likely to occur in patients
with right-sided tumors of the thoracic cavity. These
lesions often cause obstructive pneumonitis, which usu-
ally occurs with involvement of right hilar and medi-
astinal lymph nodes. Among the types of lung cancers,
all histologic cell types are associated with SVCS.
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