Journal of Turgut Özal Medical Center 3(3):1996
213
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Dr. Hakan Ekmekçi
1
,
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2
,
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1
,
Dr. Hamza Karabiber
2
,
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1
,
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1
,
Dr. Turan Arslan
3
Botulizm oldukça nadir evrensel bir enfeksiyondur. Clostridium botulinum toksini, nöromüsküler
NDYúDNODUGD YH VLQDSVODUGD YH RWRQRPLN VLQDSVODUGD DVHWLONROLQ VDOÕQÕPÕQÕ HQJHOOH\HUHN HWNL HGHU .RQWDPLQH
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Merkezi Dergisi 1996;3(3):213-216]
Anahtar Kelimeler: Botulizm, Clostridium botulinum, toksikasyon
Botulism : three case reports and general evaluation
Botulism is a very rare worldwide infection. The toxin of Clostridium botulinum acts by preventing the
release of acetylcholine at neuromuscular junctions and autonomic synapses. After eating contaminated
food, often home-canned food, a rapidly developing generalized muscle weakness occurs, affecting ocular,
facial, speech, respiratory, and autonomic muscles, as well as limb muscles. In this study, it is aimed to
enlighten the peculiar and specific features of botulism via presenting 3 clinical cases. [Journal of Turgut
Özal Medical Center 1996;3(3):213-216]
Key Words: Botulism, Clostridium botulinum, foodborne toxication
1
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DVHWLONROLQ VDOÕQÕPÕQÕ HQJHOOH\HQ Clostridium
botulinum
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7$57,ù0$
Botulinum toksini bugüne kadar bilinen en
potansiyel biyolojik zehirdir (1). Günümüzde
antijenik spesifitelerine göre 8 tip nörotoksini
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seyrek olarak yara enfeksiyonu ve infant
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°
C'de 30 dakika
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C. botulinum 3 -
48
°
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Journal of Turgut Özal Medical Center 3(3):1996
Botulism : three case reports and general evaluation
Ekmekçi H, et al.
215
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için besinler yenilmeden önce en az 10 dakika
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°
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besinde belirlenmesi ile konur. Ancak bu
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olabilmektedir. Bu nedenle, ülkemizdeki bir çok
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zehirlenmeye ve ölüme neden olabilir. Bu nedenle
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saati içinde trivalan botulinum antitoksin serumunun
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olarak 250.000 IU/kg/gün penisilin tedavisi
intravenöz ya da oral yolla verilmelidir.
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REFERANSLAR
1.
Kao I, Drachman DM. Botulinum toxin: mechanism of
presynaptic blockade. Science 1976; 173: 1256-8.
2.
McDonald TD, Lange DJ. Botulism: diagnosis and
treatment. Hospital Medicine 1992; 3: 42-57.
3.
Duchen LW, Strich SJ. The effect
of Botulism toxin on the
pattern of innervation of skeletal muscle in the mouse. Q J
Exp Physiol 1968; 53: 84.
4.
Cotran SR, Kumar V, Robbins SL. Robbins Pathologic
Basis of Disease. WB Saunders Co. Philadelphia 1989.
5.
Werner SB, Chin J. Botulism - diagnosis, management and
public health consideration. Calin Med 1973; 118: 84-9.
6.
Dowell VR. Coproexamination for botulinal toxin and
Clostridium botulinum: A new procedure for laboratory
diagnosis of botulism. JAMA 1987; 228: 1829-31.
7.
Mac
Donald KL, Cohen ML, Blake PA. The changing
epidemiology of adult botulism in the United State. Am J
Epidemiol 1986; 124: 794-800.
8.
Wilcox P, Audolfatto G, Fairborn MS, Pardy RL. Long term
follow-up of symptoms, pulmonary functions, respiratory
7XUJXW g]DO 7ÕS 0HUNH]L 'HUJLVL
%RWXOL]P ROJX VXQXPX YH JHQHO GH÷HUOHQGLUPH
H. Ekmekçi ve ark.
216
muscle strength, and exercise performance after botulism.
Am Rev Respir Dis 1989; 148: 578-83.
9.
Tacket CO, Shandera WX, Mann JM, et al. Equine antitoxin
use and other factors that predict outcome in type A
foodborne botulism. 1984; 76: 74-7.
Mehmet Buyruk Cad.
Talat Bey Sok.
Mehmet Bey Apt. 40 / 3
44300 - MALATYA