Flukonazoli abc 100mg myari kafsulebi flukonazoli abc 150mg myari kafsulebi flukonazoli abc 200mg myari kafsulebi Terapiuli jgufi



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flukonazol ABC

flukonazoli ABC 100mg myari kafsulebi

flukonazoli ABC 150mg myari kafsulebi

flukonazoli ABC 200mg myari kafsulebi

Terapiuli jgufi

triazolis sokossawinaaRmdego saSualeba sistemuri gamoyenebisTvis



Terapiuli informacia

1) kriptokokozi: flukonazoli naCvenebia Rrma sokovani infeqciebis samkurnalod, romelic gamowveulia Cryptococcus neoformans, im SemTxvevebis CaTvliT, romelic viTardeba pacientebSi imunuri sistemis meoradi dazianebiT avTvisebiani daaavdebis an SeZenili imunodeficitis sindromis gamo, an sokovani infeqciebisas, romelic gamowveulia meoradad kibos qimioTerapiis Semdeg.

preparati SeiZleba gamoyenebul iqnas kriptokokuli meningitis samkurnalod da SemanarCunebel TerapiaSi recidivis profilaqtikisTvis, kanis da filtvis kriptokokozis samkurnalod.

2) sistemuri kandidozi: kandidemiis da diseminirebuli kandidiazis da invaziuri Candida sxva infeqciebisas: ezofagiti, endokarditi, peritoniti, filtvis infeqciebi, gastrointestinuri, okularuli da genitourinaruli. pacientebi avTvisebiani daavadebebiT, romlebic imyofebian intensiuri Terapiis ganyofilebaSi da utardebaT imunosupresiuli Terapia an kibos qimioTerapia, sxva mdgomareobebi, romlebic iwvevs sokovani infeqciebisadmi ganwyobas.

3) lorwovanis kandidozi: orofaringealuri kandidozi da ezofagealuri kandidozi, arainvaziuri bronqopulmonaruli infeqciebi, kandiduria, mukokutaneuri kandidozi da qronikuli oraluri atrofiuli kandidozi. preparati agreTve naCvenebia orofaringeuli kandidozis recidivis prevenciisTvis SidsiT daaavadebul pacientebSi.

4) genitaluri kandidozi: mwvave da rekurentuli vaginaluri kandidozi: vaginaluri kandidozis profilaqtika an recidivis Semcireba (3 an meti epizodi weliwadSi). kandiduri balaniti.

5) imunokomprometirebuli pacientebi: agreTve naCvenebia im sokovani infeqciebis prevenciisTvis meoradad dazianebuli imunuri sistemis mqone pacientebSi, romlebic gamowveulia avTvisebiani daavadebiT an SeZenili imunodeficitis sindromiT, im sokovani infeqciebis prevencia, romlebic gamowveulia meoradad kibos qimioTerapiisas.

6) dermatomikozebi: tinea pedis, tinea cruris, tinea corporis, tinea capitis mravalferovani pitiriazi da kanis kandidozis mkurnaloba.

kanis da lorwovani garsis infeqciebis mkurnalobisas preparatis gamoyeneba unda iyos SezRuduli da gamoiyenon mxolod im SemTxvevebSi, rodesac adgilobrivi Terapia araefeqturi iyo.

7) Rrma endemuri mikozebi: kokcidiomikozi, parakocidiomikozi, sporotriqozi da histoplazmozi imunikompetentur pacientebSi.



gamoyeneba bavSvebSi

flukonazoli ABC ar unda gamoiyenon tinea capitis dros.

ukuCveneba

flukonazoli ABC ar unda gamoiyenon pacientebSi flukonazolis an sxva Semavseblebis mimarT momatebuli mgrZnobelobiT. misi gamoyeneba agreTve rekomendebuli ar aris mwvave da qronikuli RviZlis daavadebiTa da RviZlis ukmarisobiT daavadebul pacientebSi (ix. “usafrTxoebis zomebi gamoyenebisas”).

Cveulebriv ukunaCvenebia orsulobisa da laqtaciis dros (ix. “specialuri gafrTxilebebi”).

terfenadinis erTdrouli gamoyeneba ukunaCvenebia pacientebSi, romlebic mkurnaloben flukonazolis didi dozebiT ≥400mg/dReSi (ix. urTierTqmedebebi).

cizapridis erTdrouli gamoyeneba ukunaCvenebia pacientebSi, romlebic flukonazoliT mkurnaloben (ix. urTierTqmedebebi).



usafrTxoebis zomebi gamoyenebisas

imunokomprometirebul pacientebSi Terapia SeiZleba daiwyos kulturis laboratoriuli gamokvlevis Sedegebis miRebamde. SemdgomSi antifungaluri Terapiis adaptireba unda moxdes Sedegebis Sesabamisad.

saWiroa im pacientebis monitoringi, romlebic flukonazoliT mkurnalobis dros amJRavneben RviZlis funqciis anomaliebs. Tu RviZlis daavadebis niSnebi da simptomebi SeiZleba dakavSirebuli iyos preparatis gamoyenebasTan, misi miReba unda Sewydes.

flukonazoli dakavSirebulia RviZlis toqsiurobis iSviaT SemTxvevebTan, romlebic zogjer SeiZleba iyos fataluri, gansakuTrebiT pacientebSi seriozuli mdgomareobiT.

flukonazolTan dakavSirebuli hepatotoqsiurobis SemTxvevaSi SesaZlebeli ar iyo dozasTan, Terapiis xangrZlivobasTan pacientis sqesTan da asakTan kavSiris dadgena; es epizodebi Cveulebriv Seqcevadi iyo Terapiis Sewyvetis Semdeg.

flukonazoliT Terapiisas gamoCnda kanis reaqciebis iSviaTi epizodebi stivens-jonsonis sindromis da toqsiuri epidermaluri enkrolizis CaTvliT; SidsiT daavadebuli pacientebi ufro midrekilni arian sxvadasxva wamlebis mimarT kanis seriozuli reaqciebis ganviTarebisadmi.

Tu pacients, romelic iRebs flukonazols kanis zedapiruli sokovani infeqciis samkurnalod, ganuviTarda gamonayari preparatis miRebis Semdeg, am agentiT mkurnaloba unda Sewydes.

invaziuri/sistemuri sokovani infeqciebis mqone pacientebSi, romlebsac uviTardebaT gamonayari, unda SeCerdes flukonazoliT mkurnaloba blisterebis an mravalformuli eriTemis ganviTarebisas.

flukonazolis erTdrouli gamoyeneba doziT 400mg.dReSi terfenadinTan erTad saWiroebs monitorings (ix. agreTve urTierTqmedebebi).

zogierTi azolebi, flukonazolis CaTvliT, dakavSirebulia eleqtrokardiogramaze QT intervalis gaxangrZlivebasTan. postmarketinguli kvlevis dros pacientebSi, romlebic iRebdnen flukonazols, gamovlinda QT intervalis gaxangrZlivebis iSviaTi SemTxvevebi da torsades de pointes. es SemTxvevebi moicavda mwvaved daavadebul pacientebs mravlobiTi riskfaqtorebiT, rogorebicaa gulis struqturuli daavadeba, eleqtrolituri anomaliebi da narkotikebi. flukonazoli sifrTxiliT unda gamoiyenon proariTmiis potencialis mqone pacientebSi.



gamoyeneba Tirkmlis ukmarisobis mqone pacientebSi

flukonazoli umetesad gamoiyofa SardiT, ucvleli saxiT.

koreqcia saWiro ar aris erTjeradi doziT mkurnalobisas (vaginaluri kandidozi).

Tu ganmeorebiTi dozebis gamoyeneba xdeba Tirkmlis ukmarisobis mqone pacientebSi (bavSvebis CaTvliT), unda gamoiyenon sawyisi doza 50-400mg, Semdeg dRiuri doza (Cvenebis mixedviT) unda Seswordes Semdegi sqemis mixedviT:



kreatininis klirensi (ml/wT)

rekomendebuli doza (%)

>50

100%

≤50

50%

dializze myofi pacientebi

100% dializis yoveli proceduris Semdeg

urTierTqmedeba

antikoagulantebi: urTierTqmedebis kvlevisas, romelic moicavda mamrobiTi sqesis janmrTel moxaliseebs, flukonazolma gamoiwvia proTrombinis drosi gaxangrZliveba (12%) varfarinis miRebis Semdeg. rogorc sxva triazoluri antifungaluri saSualebebis SemTxvevaSi, aRiniSna sisxldenis movlenebi (sisxlCaqcevebi, cxviridan sisxldena, gastrointestinuri sisxldena, hematuria da melena) proTrombinis drois gaxangrZlivebasTan kombinaciaSi im pacientebSi, romlebic erTdroulad iRebdnen flukonazols da varfarins. aqedan gamomdinare, pacientebSi, romlebic iReben kumarinis antikoagulantebs rekomndebulia proTrombinis drois monitoringi.

azitromicini: Ria kvlevaSi, romelic Catarda janmrTel moxaliseebSi, romlebic oralurad iRebdnen 1200mg azitromicins da 800mg flukonazols, ar aRiniSna mniSvnelovani farmakokinetikuri urTierTqmedeba am preparatebs Soris.

benzodiazepinebi (swrafi efeqti): midazolamis da flukonazolis oralurad erTdrouli miRebis Semdeg aRiniSna midazolamis koncentraciis da fsiqomotoruli efeqtebis zrda. midazolamis efeqti ufro Zlieria flukonazolis oralurad miRebisas, vidre intravenurad gamoyenebisas. Tu pacientebi, romlebic mkurnaloben flukonazoliT, saWiroeben benzodiazepinebiT Terapias, unda gaTvaliswinebul iqnas benzodiazepinebis dozis Semcireba da amgvari pacientis adeqvaturi monitoringi.

sulfonilSardovana: janmrTel moxaliseebSi miRebisas flukonazolma gamoiwvia SratSi sulfonilSardovanas im preparatebis naxevargamoyofis periodis gaxangrZliveba, romlebis gamoyenebac xdeboda masTan erTdroulad oralurad (qlorpropramidi, glibenklamidi, glipizidi da tolbutamidi). flukonazoli da oraluri sulfonilSardovana SeiZleba erTdroulad gamoiyenon diabetiT daavadebul pacientebSi, magram unda gaiTvaliswinon hipoglikemiis SesaZlebloba.

hidroqlorTiazidi: janmrTel moxaliseebSi, romlebic iRebdnen flukonazols, hidroqlorTiazidis mravlobiTi dozebis erTdroulad miRebam gamoiwvia fluikonazolis koncentraciis 40%-iT momateba plazmaSi. es efeqti ar moiTxovs flukonazolis dozirebis reJimis koreqcias pacientebSi, romlebic iReben diuretikebs; Tumca eqimma unda gaiTvaliswinos es SesaZleblobac.

fenitoini: flukonazolis da fenitoinis erTdrouli gamoyeneba SeiZleba iwvevdes fenitoinis klinikurad mniSvnelovan dones. roca am ori preparatis miReba aucilebelia, saWiroa fenitoinis plazmuri koncentraciis kontroli da am ukanasknelis dozis modificireba, preparatis Terapiul doneSi dasarwmuneblad.

oraluri kontraceptivebi: or farmakokinetikur kvlevaSi oraluri kontraceptivebis da flukonazolis mravlobiTi dozebis erTad gamoyenebisas ar aRiniSna klinikurad mniSvnelovani efeqtebi hormonebis donisa pacientebSi, romlebic mkurnalobdnen flukonazilis 50mg-iT, roca eTilenestradiolis da levonogestrelis AUC pacientebSi, romlebic mkurnalobdnen flukonazilis 200mg-iT, gaizarda 40% da 24%-iT.

mesame kvlevaSi 300mg flukonazolis gamoyenebisas kviraSi erTxel, eTilenestradiolis da noreTindronis AUC gaizarda 24 da 13%-iT.

flukonazolis mravlobiTi dozebis gamoyeneba ar moqmedebs oraluri kontraceptivebiT kombinirebul Terapiaze.

rifampicini: flukonazolis da rifampicinis erTdrouli gamoyenebisas aRiniSna flukonazolis AUC –s 25%-iT da naxevargamoyofis periodis 20%-iT Semcireba. aqedan gamomdinare, pacientebSi, romlebic iReben rifampicins, unda gaTvaliswinebul iqnas flukonazolis dozis gazrda.

ciklosporini: farmakokinetikur kvlevaSi romelic Catarda pacientebSi, romlebsac CautardaT Tirkmlis gadanergva, gamoCnda, rom flukonazoli doziT 200mg/dReSi iwvevs ciklosporinis koncentraciis nel matebas. Tumca sxva kvlevaSi, romelic CautardaT Zvlis tvinis gadanergvis Semdeg pacientebs, mravlobiTi doziT 100mg/dReSi, flukonazolma gavlena ar moaxdina ciklosporinis doneze. aqedan gamomdinare rekomendebulia ciklosporinis plazmuri koncentraciis monitoringi pacientebSi, romlebsac flukonazoliT mkurnaloben.

Teofilini: placebo-kontrolirebul urTierTqmedebis kvlevaSi, 200mg flukonazolis gamoyenebam 14 dRis ganmavlobaSi gamoiwvia Teofilinis plazmuri koncentraciis 18%-iT Semcireba. pacientebSi, romlebsac mkurnaloben Teofilinis maRali dozebiT an aReniSnebaT TeofiliniT toqsiurobis maRali riski, saWiroa monitoringi flukonazolis erTdrouli gamoyenebisas. Tu SeniSnavT TeofiliniT toqsiurobis niSnebs, mkurnalobis modificirebaa saWiro.

terfenadini: disriTmiis mwvave epizodebis Semdeg (QT gaxangrZliveba) pacientebSi, romlebic itareben mkurnalobas antifungaluri azolebiT da terfenadiniT, urTierTqmedebis kvlevebi Catarda terfenadinsa da flukonazolze. flukonazolis dRiurma dozam 200mg ar gamoiwvia QT gaxangrZliveba. dRiurma dozam 400mg da meti, sagrZnoblad gazarda terfenadinis plazmuri koncentracia. flukonazolis erTdrouli gamoyeneba doziT 400mg/dReSi an ufro meti ukunaCvenebia (ix.ukuCvenebebi). flukonazolis erTdrouli gamoyeneba 400mg/dReSi dabali doziT saWiroebs monitorings.

cizapridi: pacientebSi, romlebic itarebdnen mkurnalobas flukonazoliT da cizapridiT ariniSna gulis movlenebis SemTxvevebi torsades de pointes CaTvliT. kontrolriebul kvlevaSi aRiniSna, rom flukonazolis 200mg gamoyeneba 1X dReSi da cizapridis 20mg gamoyeneba 4X dReSi iwvevs plazmaSi cizapridis koncentraciis mniSvnelovan momatebas da QT gaxangrZlivebas. cizapridis da flukonazolis erTdrouli gamoyeneba ukunaCvenebia (ix.ukuCvenebebi).

rifabutini: flukonazolis da rifabutinis erTdrouli gamoyenebisas aRiniSna urTierTqmedeba, romelic xasiaTdeboda rifabutinis koncentraciis momatebiT. aRwerilia nefrotoqsiurobis SemTxvevebi pacientebSi, romlebSic flukonazoli da rifabutini gamoiyeneboda. aqedan gamomdinare, rifabutinis da fluikonazolis erTdrouli gamoyenebisas saWiroa pacientebis monitoringi.

takrolimusi: flukonazolis da takrolimusis erTdrouli gamoyenebisas aRiniSna urTierTqmedeba, romelic xasiaTdeboda takrolimusis koncentraciis momatebiT. aRwerilia nefrotoqsiurobis SemTxvevebi pacientebSi, romlebSic flukonazoli da takrolimusi gamoiyeneboda. aqedan gamomdinare, rifabutinis da takrolimusis erTdrouli gamoyenebisas saWiroa pacientebis monitoringi.

zidovudini: or farmakokinetikur kvlevaSi flukonazolis da zidovudinis gamoyenebisas aRiniSna zidovudinis donis zrda, romelic gamowvuli iyo zidovudinis gardaqmnis SeferxebiT mis ZiriTad metabolitebad. pirvel kvlevaSi, romelic Catarda SidsiT daavadebul pacientebSi an pacientebSi SidsTan dakavSirebuli garTulebebiT, ganisazRvra zidovudinis done 200mg/dReSi flukonazolis miRebamde da mis Semdeg 15 dRis ganmavlobaSi da aRiniSna zidovudinis AUC mniSvnelovani zrda (20%).

meore jvaredin randomizebul kvlevaSi, romelic Catarda sxvdasxva dros flukonazolis da zidovudinis erTad gamoyenebisas, gamoikvlies zidovudinis done aiv inficirebul pacientebSi. orjer, 21 dRis Semdeg, pacientebSi gamoyenebuli iyo 7 dRis ganmavlobaSi 200mg zidovudini yovel 8 saaTSi, romelic dakavSirebuli iyo da ar iyo dReSi 400mg flukonazolis miRebasTan. zidovudinis AUC gaizarda mniSvnelovnad (74%) flukonazolTan erTad gamoyenebisas. aqedan gamomdinare, pacientebSi, romlebic itareben erTdroul mkurnalobas 2 preparatiT saWiroa monitoringi zidovudinTan dakavSirebuli gverdiTi movlenebis ganviTarebis SesaZleblobis gamo.

flukonazolis gamoyeneba pacientebSi, romlebic itareben mkurnalobas astemizoliT an citoqrom P450-iT metabolizebadi sxva preparatebiT, SeiZleba dakavSirebuli iyos SratSi am preparatebis koncentraciis momatebasTan. gansazRvruli informaciis ararsebobisas, flukonazolis gamoyenebisas rekomendebulia sifrTxile, saWiroa pacientebis monitoringi.

klinikurad mniSvnelovani urTierTqmedeba ar aRiniSna flukonazolis da ciemtidinis an antacidebis erTad gamoyenebisas. pacientebSi, romlebsac utardebodaT sxeulis totaluri dasxiveba Zvlis tvinis transplantaciisTvis, ar aRiniSneboda klinikurad mniSvnelovani cvlilebebi flukonazolis absorbciaSi.

gaafrTxileT Tqveni eqimi an farmacevti Tu ukanasknel dros miRebuli gaqvT sxva wamlebi, receptis gareSe gacemuli preparatebis CaTvliT.

flukonazoli ABC gamoyeneba sakvebTan da sasamelTan erTad

flukonazoli ABC ar urTierTqmedebs sakvebTan da sasmelTan.



specialuri gafrTxilebebi

orsuloba da laqtacia

ar arsebobs adeqvaturad kontrolirebadi klinikuri kvlevebi orsul qalebSi.

axalSobilebSi, romelTa dedebsac aReniSnebodaT kokcidiomikozi da mkurnalobdnen flukonazolis maRali dozebiT (400-800mg/dReSi) ≥3Tvis ganmavlobaSi, aRiniSna mravlobiTi kongenitaluri anomaliebi.

flukonazolis gamoyenebasa da am movlenebs Soris kavSiri gaurkvevelia.

cxovelebis reproduqciul kvlevebSi gamoCnda nayofis dedis toqsiurobasTan dakavSirebuli dazianeba - mxolod preparatis maRali dozebis gamoyenebisas, magram ar gamomJRavnebula, rodesac preparati gamoiyeneboda doziT 5-10mg/kg. orsulobis dros preparatis gamoyeneba unda iyos SezRuduli da moxdes mxolod mZime sokovani infeqciebisas, rodesac eqimis azriT potenciuri sargebeli aWarbebs potenciur safrTxes (ix.ukuCveneba). flukonazolis done, romelic aRiniSneba dedis rZeSi, plazmis donis msgavsia, aqedan gamomdinare preparatis gamoyeneba laqtaciis dros rekomendebuli ar aris (ix.ukuCveneba).

nebismieri preparatis miRebamde rCeva hkiTxeT eqims an farmacevts.

gavlena transportis marTvasa da meqanizmebis gamoyenebaze

flukonazolis gamocdileba aCvenebs, rom es preparati Cveulebriv ar moqmedebs pacientis avtomobilis marTvisa da meqanizmebis gamoyenebis unarze. miuxedavad amisa, iSviaTad, SesaZlebelia Tavbrusxveva (ix.gvrdiTi efeqtebi). amis gamo, pacienti frTxilad unda iyos manqanis marTvis an meqanizmebTan muSaobisas.



mniSvnelovani informacia flukonazoli ABC zogierTi Semavseblis Sesaxeb:

produqti Seicavs laqtozas. misi gamoyeneba ar SeiZleba laqtozis Tandayolili autanlobis an glukoza-galaqtozas malabsorbciis mqone pacientebSi.



miRebis dro, meTodi da doza

flukonazolis dRiuri doza dafuZnebuli unda iyos sokovani infeqciis bunebasa da simwvaveze.

vaginaluri kandidozis SemTxvevaTa umetesoba reagirebs erTjerad dozaze.

im infeqciebis mkurnaloba, romelic mravlobiT dozas moiTxovs, unda gagrZeldes, vidre klinikuri parametrebi da laboratoriuli testebi ar aCvenebs, rom sokovani infeqcia aRar arsebobs.

mkurnalobis araadeqvaturma periodma SeiZleba gamoiwvios aqtiuri infeqciis recidivi. SidsiT daavadebuli da kriptokokuli meningitis, orofaringeuli kandidozis recidivis mqone pacientebi Cveulebriv moiTxoven mkurnalobis SenarCunebas recidivis profilaqtikisTvis.

gamoyeneba mozrdilebSi

1) kriptokokozi

seriozuli daavadebisTvis, romelmac Seizleba daazianos pacientis sicocxle kriptokokuri meningitis CaTvliT, Cveuli dozaa 400mg dReSi pirvel dRes. Semdeg dReebSi rekomendebuli dozaa 200mg/dReSi.

pacientis klinikuri pasuxis mixedviT, doza SeiZleba gaizardos 400mg-mde dReSi. zogadad kriptokokuri meningitis mkurnalobis xangrZlivoba 6-8 kviraa. SidsiT daavadebul pacientebSi kriptokokuri meningitis recidivis prevenciisTvis flukonazolis gamoyeneba SeiZleba ganusazRvrelad doziT 200mg dReSi, mas Semdeg, rac pacienti daasrulebs Terapiis pirvel cikls da kulturanegatiuri gaxdeba.

2) sistemuri kandidozi

kandidemiis, diseminirebuli kandidozis da sxva invaziuri sokovani infeqciebisTvis Cveulebrivi dozaa 400mg pirvel dRes. Semdgomi rekomendebuli dozaa 200mg/dReSi. pacientis klinikuri pasuxis mixedviT doza SeiZleba gaizardos 400mg-mde dReSi. mkurnalobis xangrZlivoba damokidebulia klinikur pasuxze.

3) lorwovanis kandidozi

orofaringeuli kandidozisTvis, imunokomprometirebuli pacientebis CaTvliT, Cveuli dozaa 50-100mg dReSi erTxel 7-14 dRis ganmavlobaSi. aucileblobisas, mwvave imunokomprometirebul pacientebSi mkurnaloba SeiZleba gagrZeldes ufro xangrZlivad.

atrofiuli oraluri kandidozisTvis, proTezebisas, Cveuli dozaa 50mg dReSi erTxel 14 dRis ganavlobaSi. am SemTxvevebSi saWiroa piris Rrus damxmare antiseptikuri mkurnaloba da proTezis antiseptikuri damuSaveba.

sokovani infeqciebisTvis (genitaluri kandidozis garda, romelic mocemulia Semdeg paragrafSi), rogorebicaa ezofagiti, kandiduria, arainvaziuri bronqopulmonaruli infeqciebi, mukokutaneuri kandidozi da sxva, Cveulebrivi efeqturi dozaa 50-100mg dReSi 14-30 dRe. orofaringeuli kandidozis redicivis prevenciisTvis SidsiT daavadebul pacientebSi, mas Semdeg, rac pacienti gaivlis pirveladi Terapiis mTel kurss, flukonazolis gamoyeneba SeiZleba 150mg doziT kviraSi erTxel.

4) genitaluri kandidozi

vaginaluri kandidozis samkurnalod, erTjeradi dozaa 150mg 1 dRe.

vaginuri kandidozis recidivis Sesamcireblad SeiZleba gamoyenebul iqnas flukonazolis 150mg TveSi erTxel 4-12 Tvis ganmavlobaSi. zogierT pacientSi SeiZleba saWiro gaxdes ufro xSiri gamoyeneba.

sokovani balanitis dros dozaa 150mg erTeuli oraluri miRebisTvis.

5) imunokomprometierbuli pacientebi

kandidozis prevenciisTvis, flukonazolis rekomendebuli dozaa 50-400mg 1X dReSi, sokovani infeqciis ganviTarebis riskis mixedviT. maRali riskis pacientebSi, an pacientebSi, romlebSic SeiZleba ganviTardes gaxangrZlivebuli neiTropenia, rekomendebuli dRiuri dozaa 400mg erTeuli doziT.

flukonazolis gamoyeneba unda daiwyos ramdenime dRiT adre neiTropeniamde da gagrZeldes 7 dRe, mas Semdeg, rac neitrofilebis ricxvi miaRwevs 1000 ujredi/mm3-ze mets.

6) dermatomikozi

dermatomikozisas tinea pedis, corporis, cruris, mravlobiTi pitiriazis da kanis sokovani infeqciebis CaTvliT Cveuli dozaa 50-100 mg dReSi erTjeradi dozis saxiT 2-4 kviris ganmavlobaSi. tinea pedis SeiZleba moiTxovdes mkurnalobas 6 Tveze didi xnis ganmavlobaSi.

7) Rrma endemuri mikozi

Rrma endemuri sokovani infeqciisas preparati unad miiRon Semdegi sqemis mixedviT:



infeqciis tipi

doza

mkurnalobis xangrZlivoba

kokcidiomikozi

200-400mg

11-24Tve

parakokcidiomikozi

200-400mg

2-17Tve

sporotriqozi

200-400mg

1-16Tve

histoplazmozi

200-400mg

3-17Tve

gamoyeneba bavSvebSi

rogorc mozridilebis infeqciisas, mkurnalobis xagrZlivoba damokidebulia klinikur da mikogenur pasuxze.

flukonazolis gamoyeneba xdeba erTjeradi dRiuri dozis saxiT.

bavSvebSi Tirkmlis dazianebuli funqciiT, ixileT dozireba “gamoyeneba pacientebSi Tirkmlis ukmarisobiT” paragrafSi “usafrTxoebis Sesabamisi zomebi gamoyenebisas”

4kviraze meti asakis bavSvebi

lorwovani garsebis kandidozisas rekomendebuli dozaa 3 mg/kg/dReSi. 6 mg/kg/dReSi SeiZleba gamoiyenon pirvel dRes myari mdgomareobis ufro male misaRwevad.

sistemuri kandidozis da kriptokokuri infeqciebis samkurnalod, rekomendebuli dozaa 6-12 mg/kg/dReSi, daavadebis simwvaveze damokidebulebiT.

sokovani infeqciebis profilaqtikisTvis imunokomprometirebul pacientebSi, romlebsac aReniSnebaT neiTropeniis riski, gamowveuli citotoqsiuri an radioTerapiiT, rekomendebuli dozaa 3-12 mg/kg neiTropeniis donis da xangrZlivobis mixedviT (ix. dozireba mozrdilebSi).

bavSvebSi maqsimalurma dRiurma dozam ar unda gadaaWarbos 400mg-s.

bavSvebi sicocxlis pirveli 4 kviris ganmavlobaSi

axalSobilebSi flukonazoli gamoiyofa ufro nela. sicocxlis pirveli ori kviris ganmavlobaSi SeiZleba igive dozis gamoyeneba mg/kg-Si rogorc bavSvebis sxva jgfebSi, magram yovel 72 saaTSi. mesame da meoTxe kviris ganmavlobaSi unda mieces igive doza 48 saaTSi erTxel. axalSobilobis bolo periodSi arsebobs farmakokinetikis Raribi monacemebi dozirebis mxardasaWerad.

pirveli ori kviris ganmavlobaSi axalSobilelbSi dozam ar unda gadaaWarbos 12mg/kg-s yovel 72 saaTSi, mesame da meoTxe kviris ganmavlobaSi ki 12mg/kg-s yovel 48 saaTSi.

flukonazolis farmakokinetika Tirkmlis ukmarisobis mqone bavSvebSi Seswavlili ar aris.



gamoyeneba xandazmulebSi

Tu ar arsebobs Tirkmlis dazianebis mtkicebuleba, gamoiyeneba normaluri doza. pacientebSi Tirkmlis dazianebuli funqciiT (kreatininis klirensi <50ml/wT), dozireba unda moxdes sqemis mixedviT, romelic naCvenebia paragrafSi “usafrTxoebis Sesabamisi zomebi gamoyenebisas”.



miRebis meTodi

flukonazoli SeiZleba gamoiyenon oralurad an intravenurad.

miRebis gza damokidebulia pacientis klinikur mdgomareobaze.

intravenuridan oralur gzaze an piriqiT gadasvlisas, dRiuri dozirebis cvlileba saWiro ar aris.



flukonazoli ABC SefuTulia rogorc kafsulebi oraluri gamoyenebisTvis. ar arsebobs saineqcio forma intravenuri gamoyenebisTvis.

flukonazoli ABC-s gamoyenebaze raime eWvis SemTxvevaSi mimarTeT eqims an farmacevts.

Warbi dozireba

aRwerilia flukonazolis Warbi dozirebis SemTxvevebi. erT-erTSi (42 wlis aiv inficirebuli mamakaci), pacients aReniSneboda halucinaciebi da paranoiduli qceva 8200mg flukonazolis ineqciis Semdeg. pacienti hospitalizebul iqna, misi mdgomareoba mogvarda 48 saaTSi.

Warbi dozirebis SemTxvevaSi, saWiroa simptomuri mkurnaloba (Sesabamisi mkurnalobiT, aucileblobisas kuWis lavaJiT). flukonazoli gamoiyofa SardSi, forsirebuli diurezi savaraudod gazrdis eliminaciis siswrafes. 3 saaTiani hemodializis procedura plazmaSi dones aqveiTebs daaxloebiT 50%-iT.

flukonazol ABC-s Warbi dozis SemTxveviTi miRebisas, dauyovnebliv acnobeT Tqvens eqims an mimarTeT uaxloes saavadmyofos.



gverdiTi efeqtebi

rogorc yvela preparatma, flukonazol ABC-m SeiZleba gamoiwvios gverdiTi efeqtebi, magram is yvelas ar aReniSneba.

yvelaze xSiri gevrdiTi efeqtebi gamovlenili flukonazolis klinikuri kvlevebisas Semdegia:

gastrointestinuri darRvevebi: muclis tkivili, diarea, meteorizmi, gulsreva.

kanis da kanqveSa qsovilis darRvevebi: gamonayari.

nervuli sistemis darRvevebi: Tavis tkivili.

zogierT pacientSi, gansakuTrebiT seriozuli daavadebiT, rogoricaa Sidsi an kibo, aRiniSna cvlilebebi RviZlis, Tirkmlis da hematologiur funqciaSi flukonazoliT mkurnalobisas, magram klinikuri mniSvneloba da mkurnalobasTan korelacia gaurkvevelia.

hepatobiliaruli darRveebi: RviZlis toqsiuroba iSviaTi fataluri SemTxvevebis CaTvliT, tute fosfatazas momateba, bilirubinis momateba, transaminazebis (ast) da alt momateba.



pediatriuli populacia

gverdiTi efeqtebis tipi da sixSire da laboratoriuli anomaliebi aRwerili bavSvebis klinikur kvlevebSi SedarebiTia mozridlebSi aRniSnulTan.

Tumca, flukonazolis marketingis Semdeg aRmoCnda Semdegi gverdiTi efeqtebi:

gastrointestinuri darRvevebi: dispefsia, Rebineba

nervuli sistemis darRvevebi: Zilianoba, krunCxvebi, gemovnebis cvlileba.

kanis da kanqveSa qsovilis darRvevebi: alopecia, eqsfoliaciuri kanis reaqciebi stivens-jonsonis sindromis da toqsiuri epidermaluri nekrolizis CaTvliT.

sisxlis da limfuri sistema: leikopenia neiTropeniis da agranulocitozis CaTvliT, Trombocitopenia.

imunuri sistemis darRvevebi: anafilaqsia (angioedemis, saxis SeSupebis, qavilis, urtikariis CaTvliT).

hepatobiliaruli darRvevebi: RviZlis ukmarisoba, hepatiti, hepatocelularuli nekrozi, siyviTle.

metabolizmis da kvebis darRvevebi: hiperqolesterolemia, hipertrigliceridemia, hipokaliemia.

gulis mxriv darRvevebi: QT intervalis gaxangrZliveba, torsades de pointes (ix.agreTve “Sesabamisi usafrTxoebis zomebi gamoyenebisas”).

Tu romelime gverdiTi efeqti gamwvavdeba, an SeniSnavT gverdiT efeqts, romelic broSuraSi mocemuli ar aris, mimarTeT Tqvens eqims an farmacevts.

vargisobis vada da Senaxva

inaxeba araumetes 30°C temperaturaze.

gamoyeneba ar SeiZleba SefuTvaze miTiTebuli vargisobis vadis gasvlis Semdeg.

vargisobis vada Seesabameba intaqtur SefuTvas, sworad Senaxuls.

gamoyeneba ar SeiZleba dazianebis niSnebis aRmoCenisas.

preparatebi gadagdebuli ar unda iqnas sayofacxovrebo nagavTan erTad. hkiTxeT farmacevts rogor gaanadguroT arasaWiro medikamentebi, es xels Seuwyobs garemos dacvas.

inaxeba bavSvebisTvis miuwvdomel adgilas.

Semadgenloba

flukonazoli ABC 100mg myari kafsulebi:

1kafsula Seicavs: aqtiuri nivTiereba: flukonazoli 100mg

Semavseblebi: laqtozis monohidrati, preJelatinizebuli saxamebeli, magneziis stearati, siliciumi koloiduri uwylo, natriumis lauril sulfati.

kafsula: Jelatini, titanis dioqsidi (E171), rkinis yviTeli oqsidi (E172).



flukonazoli ABC 150mg myari kafsulebi:

1kafsula Seicavs: aqtiuri nivTiereba: flukonazoli 150mg

Semavseblebi: laqtozis monohidrati, preJelatinizebuli saxamebeli, magneziis stearati, siliciumi koloiduri uwylo, natriumis lauril sulfati.

kafsula: Jelatini, titanis dioqsidi (E171).



flukonazoli ABC 200mg myari kafsulebi:

1kafsula Seicavs: aqtiuri nivTiereba: flukonazoli 200mg

Semavseblebi: laqtozis monohidrati, preJelatinizebuli saxamebeli, magneziis stearati, siliciumi koloiduri uwylo, natriumis lauril sulfati.

kafsula: Jelatini, titanis dioqsidi (E171),



konteineris buneba da Seadgenloba

myari kafsulebi

-kolofi Seicavs 10 kafsulas 100mg

-kolofi Seicavs 2 kafsulas 150mg

-kolofi Seicavs 7 kafsulas 200mg

marketingis uflebis mflobeli

ei bi si farmaceutiCi s.p.a-korso vittorio emanuel II, 72-torino



mwarmoebeli

laboratorio farmaceutiko k.t.s.r.l.

via dante aligieri 71,

18038 sanremo (imperia)

abc farmaceutiCi s.p.a

kanton moretti, 29

10090 san bernardo d’ivera (to)

saboloo makontrolebeli

get s.r.l via ariosto, 17



18038 sanremo (imperia)
teqstis gadaxedvis TariRi: aprili 2010





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