1 friday, april 19 Biochemistry and Molecular Biology asbmb graduate and postdoctoral travel award keynote lecture special Session

Biochemistry and Molecular Biology

197.  ASBMB BOSTON TEA PARTY: 

UNDERGRADUATE BREAKFAST SESSION  

WITH OLKE C. UHLENBECK

Special Session

(Supported by an educational grant from the National 

Science Foundation)

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Advance event registrants receive priority seating. 

All other undergraduates will be accommodated as space 

permits.

198.  ASBMB YOUNG INVESTIGATOR AWARD 

LECTURE

Award

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Introductory remarks. 

J. M. Berg.

8:35 

198.1 

GTPase and ATPase tangos during intracellular 

protein targeting. 

S-o. Shan. Caltech.

199.  ASBMB-MERCK AWARD LECTURE

Award

(Supported by an educational grant from Merck)

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Introductory remarks. 

S. Emr.

9:10 

199.1 

Biogenesis of transport carriers. 

V. Malhotra. 

Ctr. for Genomic Regul., Barcelona.

200.  MECHANISMS AND CONTROL OF 

REPLICATION INITIATION

Symposium

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Chair’s introduction.

10:00 

200.1 

Forkhead (Fox) transcription factors open 

a new dimension in understanding the epigenetic control of 

replication origins in S. cerevisiae. 

O. Aparicio, S.R.V. Knott, 

Z.A. Ostrow, J.M. Peace, Y. Gan, R. Kalhor, L. Chen and S. 

Tavaré. Univ. of Southern California.

10:25   

Mapping DNA replication origins in the human 

genome. 

S.A. Gerbi, J. Urban and M. Foulk. Brown Univ. 

(759.1)

MONDAY ANATOMY/BIOCHEMISTRY 

54

10:40 

200.2 

Controlling genome integrity via 

posttranslational regulation of the eukaryotic replisome. 

K. 

Labib. Univ. of Manchester.

11:05   

Modulation of Mcm2-7 activity by Cdt1. 

L.F. 

DaSilva, T. Kolaczyk, X. Ma and M.J. Davey. Univ. of Western 

Ontario. 

(539.2)

11:20   

Functional characterization of Dbf4 interactions 

with DNA replication and checkpoint factors. 

D.R. Jones, L.A. 

Matthews, B.J. McConkey, A. Guarné and B.P. Duncker. 

Univ. of Waterloo and McMaster Univ., Canada. 

(542.10)

11:35 

200.3 

Mechanism of eukaryotic helicase loading and 

activation. 

S.P. Bell, S. Kang, S. Ticau and B.S.H. Chan. MIT/

HHMI.

12:00   

Discussion and closing remarks.

201.  MAKING AND USING RNA IN THE NUCLEUS

Symposium

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Chair’s introduction.

10:00 

201.1 

Telomerase holoenzyme assembly. 

K. Collins. 

Univ. of California, Berkeley.

10:25  Insights into splicing: structure of the yeast U1 snRNP. 

C. van der Feltz, N. Grigorieff and D. Pomeranz Krummel. 

Brandeis Univ. and HHMI, Chevy Chase, MD. 

(988.5)

10:40 

201.2 

Regulation of alternative splicing. 

K. Hertel, 

W. Mueller, A. Busch, S. Erkelenz and H. Schaal. Univ. of 

California, Irvine and Heinrich Heine Univ., Germany.

11:05   

NOL11, implicated in the pathogenesis of 

North American Indian childhood cirrhosis, is required for pre-

rRNA transcription and processing. 

S. Baserga, E. Freed, J-L. 

Prieto, K. McCann and B. McStay. Yale Sch. of Med. and Natl. 

Univ. of Ireland Galway. 

(552.1)

11:20   

A highly conserved GC-rich element regulates 

alternative splicing of mRNA for the variant thyroid hormone 

receptor, TR

a2. S.H. Munroe. Marquette Univ. (775.2)

11:35 

201.3 

Mechanisms for regulating splicing through 

signaling pathways. 

K.W. Lynch. Univ. of Pennsylvania.

12:00   

Discussion and closing remarks.

202.  LIPID MEMBRANE CURVATURE IN MEMBRANE 

FUNCTION

Symposium

(Supported by an educational grant from Avanti Polar 

Lipids, Inc.)

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Chair’s introduction.

10:00 

202.1 

Spatiotemporal control of endocytosis by 

phosphatidylinositol 3,4-bisphosphate. 

V. Haucke and Y. 

Posor. Leibniz Inst. for Molec. Pharmacol., Berlin.

10:25   

Investigating the molecular basis of cPLA2

a 

membrane bending. 

K.E. Ward, J.P. Ropa and R.V. Stahelin. 

Univ. of Notre Dame and Indiana Univ. Sch. of Med. at South 

Bend. 

(587.3)

10:40 

202.2 

Separation of time-scales in the functional 

biophysics of bar domain proteins. 

T. Baumgart. Univ. of 

Pennsylvania.

11:05   

Novel role of cytohesin-2 in regulation of 

macropinocytosis pathway and cell proliferation. 

V. Marshansky, 

H. Hosokawa, Z. Zhuang, P.A. Randazzo, G. Grüber and 

D.A. Ausiello. Massachusetts Gen. Hosp., Harvard Med. Sch., 

NCI, NIH and Nanyang Tech. Univ., Singapore. 

(591.8)

11:20   

The Coffin-Lowry syndrome-associated protein 

RSK2 regulates neurite outgrowth through phosphorylation of 

PLD1 and synthesis of phosphatidic acid, a membrane curving 

fusogenic lipid. 

N. Vitale, M.R. Ammar and M-F. Bader. CNRS 

UPR-3212, Strasbourg. 

(587.1)

11:35 

202.3 

Exocytic and endocytic mechanisms: 

discovering a role for membrane curvature and curvature 

stress. 

H.T. McMahon. MRC Lab. of Molec. Biol., Cambridge, 

U.K.

12:00   

Discussion and closing remarks.

203.  CATALYTIC AND SUBSTRATE PROMISCUITY

Symposium

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Chair’s introduction.

10:00 

203.1 

Multiple catalytic promiscuity: specificity and 

efficiency in the alkaline phosphatase superfamily. 

F. Hollfelder. 

Univ. of Cambridge, U.K.

10:25   

Substrate specificity of Rv0045c, a bacterial 

esterase from Mycobacterium tuberculosis. 

C.P. Savas, A. 

Gehring, R.J. Johnson and G. Hoops. Butler Univ. (559.2)

10:40 

203.2 

Enzyme recruitment and the evolution of new 

metabolic potential. 

B.G. Miller. Florida State Univ.

11:05   

The role of modulator residues in PDZ domain 

binding interactions. 

J. Amacher, P.R. Cushing, L. Brooks, 

P. Boisguerin and D.R. Madden. Dartmouth Col. and Inst. of 

Med. Immunol., Berlin. 

(559.6)

11:20   

Tracking GPCR promiscuity at the source: how 

receptor conformation is translated to differential function. 

S. 

Sivaramakrishnan and R.U. Malik. Univ. of Michigan. (559.5)

11:35 

203.3 

The remarkable pliability and promiscuity of 

specialized metabolism. 

J.P. Noel. Salk Inst./HHMI.

12:00   

Discussion and closing remarks.

204.  PROTEIN PHOSPHORYLATION NETWORKS

Symposium

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Chair’s introduction.

10:00 

204.1 

Signaling by the cJun NH

2

-terminal kinase. 

R.J. Davis. HHMI and Univ. of Massachusetts Med. Sch.

10:25   

A BRAF-MEK complex reveals the molecular 

basis of oncogenic mutations. 

S.G. Hymowitz, J. Sudhamsu, 

J. Haling, A. Peck, I. Yen, T. Morales, B. Brandhuber and S. 

Malek. Genentech, South San Francisco and Array BioPharma, 

Boulder. 

(1031.11)

10:40 

204.2 

Proteomics and the control of MAP kinase 

dynamics. 

N. Ahn, Y. Xiao, T. Lee, L. Warner, M. Latham, A. 

Tanimoto, W. Peti, R. Page and A. Pardi. Univ. of Colorado 

Boulder and Brown Univ.

BIOCHEMISTRY MONDAY

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Investigating inactive conformations of protein 

kinases. 

S.B. Hari, B.G.K. Perera, S.E. Leonard and D.J. 

Maly. Univ. of Washington. (1042.1)

11:20   

The dark side of protein kinases: FRET toolbox 

illuminates a hidden conformation in PKC catalysis. 

C.J. 

Swanson, M. Ritt, B. Udarasayan, W. Wang, M. Westfall and 

S. Sivaramakrishnan. Univ. of Michigan. (597.3)

11:35 

204.3 

Novel secreted protein kinases. 

J.E. Dixon. 

HHMI, Chevy Chase, MD and UCSD.

12:00   

Discussion and closing remarks.

205.  TRANSITIONING FROM STUDENT TO 

PROFESSIONAL

Symposium

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Chair’s introduction.

10:00 

205.1 

The first big leap, college to graduate school. 

P.J. Kennelly. Virginia Tech.

10:25  

Student conceptions and misconceptions 

about energy transformations in biochemistry. 

A.J. Wolfson, 

S.L. Rowland, G.A. Lawrie and T.H. Wright. Wellesley Col. 

and Univ. of Queensland, Australia. 

(838.3)

10:40 

205.2 

NIH support of pre- and postdoctoral training 

for a career as a research scientist. 

R.E. Ulane. OD, NIH.

11:05 

 

The Pre-health Collection within 

MedEdPORTAL’s iCollaborative: faculty resources to prepare 

students for the MCAT2015. 

H.V. Jakubowski and L.S. 

Zapanta. Col. of Saint Benedict, St. John’s Univ., MN and Univ. 

of Pittsburgh. 

(838.2)

11:20  A certificate program to help bachelor’s degree graduates 

transition into careers in the bioscience industry. 

M. Wallert 

and J. Provost. Minnesota State Univ. Moorhead. (838.15)

11:35 

205.3 

The presidential postdoctoral program at 

Novartis Institutes for BioMedical Research. 

L. Pond. Novartis 

Insts. for BioMed. Res.

12:00   

Discussion and closing remarks.

206.  ASBMB CERTIFICATION PROGRAM FOR 

BACHELOR’S DEGREES IN BIOCHEMISTRY, 

MOLECULAR BIOLOGY AND RELATED 

MAJORS

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ASBMB has initiated the roll-out of an outcomes-based 

degree certification program for undergraduates majoring 

in Biochemistry, Molecular Biology, and related majors. 

The objectives of the program are to recognize student 

accomplishment and provide faculty with tools and data to help 

foster quality education and leverage needed resources. For this 

program to be successful, the participation of and feedback from 

members of the educational community is essential. Members 

of the working group responsible for developing the bachelor’s 

degree accreditation program will briefly describe the structure 

and rationale behind version 1.0 of the program, answer questions 

from the audience and receive community feedback.

207.  ALICE AND C.C. WANG AWARD IN MOLECULAR 

PARASITOLOGY SYMPOSIUM

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Introductory remarks. 

K. Kam and M. Phillips.

12:35 

207.1 

Amino acid utilization in intraerythrocytic 

malaria parasites. 

D.E. Goldberg. HHMI/Washington Univ.

1:05 

207.2 

Scent of a parasite: isoprenoids in malaria. 

A.R. Odom. Washington Univ. Sch. of Med.

1:35 

207.3 

What do human parasites do with a chloroplast 

anyway? 

B. Striepen. Univ. of Georgia.

2:05  

Conclusion.

208.  FROM THE LAB TO THE KITCHEN TABLE –  

COMMUNICATING SCIENCE TO A LAY 

AUDIENCE

Workshop

(Sponsored by: ASBMB Public Outreach Committee)

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Outreach can come in a wide variety of flavors. Come get a 

taste during our interactive roundtable session.  

•  “Science and Me” – a student-driven science outreach 

program for adult audiences 

H. Alexander, Univ. of Missouri-

Columbia

•  Takin’ It to the Streets 

P.A. d’Arbeloff Cambridge Sci Fest 

•  Learning to Communicate—A Graduate Training Course 

in Science Communication 

T. Baldwin Univ. of California, 

Riverside

•  Community-Based Projects That Complement Learning in a 

Biochemistry Course

 J. Dattelbaum Univ. of Richmond 

•  The Science & Entertainment Exchange: 1-800-I-Need-a-

Scientist! 

A. M. Merchant The Science and Entertainment 

Exchange 

•  FameLab: Communicating Your Science

 D. M. Scalice NASA 

Astrobiology Inst. 

•  Do-it-Yourself: Building the Voice of Young Science,

  

M. Thompson, Harvard Univ

209.  DELANO AWARD FOR COMPUTATIONAL 

BIOSCIENCES LECTURE

Award

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Introductory remarks. 

A. Stock.

3:00 

209.1 

PDB as a public resource for enabling protein 

science. 

H.M. Berman. Rutgers, The State Univ. of New Jersey, 

Piscataway.

MONDAY BIOCHEMISTRY

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210.  TRANSCRIPTION MECHANISMS

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Chair’s introduction.

3:50 

210.1 

Post-initiation roles for the sigma subunit of 

bacterial RNA polymerase. 

A. Hochschild, P. Deighan, N. 

Nair, K. Berry, S. Goldman and B. Nickels. Harvard Med. Sch. 

and Rutgers Univ., Piscataway.

4:15 

 

The X-ray crystal structure of Escherichia coli 

RNA polymerase 

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 holoenzyme. 

K. Murakami. Penn State. 

(547.2)

4:30 

210.2 

Proteomic analysis of Pol II preinitiation 

complexes: the roles of mediator and saga. 

M. Carey. UCLA.

4:55 

 

Capturing the transient, in vivo binding partners 

of transcriptional activators using a genetically incorporated 

photo-crosslinking amino acid. 

A. Dugan and A.K. Mapp. Univ. 

of Michigan. 

(550.15)

5:10   

Characterization of the interaction between 

Rrn3 and rpa43: identification of a peptide that inhibits rDNA 

transcription and cell growth. 

L. Rothblum, Y. Penrod and K. 

Rothblum. Univ. of Oklahoma Hlth. Sci. Ctr. (549.3)

5:25 

210.3 

Analysis of RNA polymerase II transcription 

initiation and elongation complexes. 

S. Buratowski. Harvard 

Med. Sch.

5:50 

 

Discussion and closing remarks.

211.  GLYCOSYLTRANSFERASES THAT CONTROL 

CELL GROWTH AND DIFFERENTIATION

Symposium

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Chair’s introduction.

3:50 

211.1 

Molecular regulation of protein O-glycosylation 

and relevance to disease and development. 

R.D. Cummings, 

Y. Wang and T. Ju. Emory Univ. Sch. of Med.

4:15   

ST6Gal-i-mediated sialylation of Fas and 

TNFR1 controls receptor localization and apoptotic signaling. 

M.J. Schultz, A.F. Swindall, Z. Liu and S.L. Bellis. Univ. of 

Alabama at Birmingham. 

(592.3)

4:30 

211.2 

Roles for glycans in mammalian development 

and spermatogenesis. 

P. Stanley, F. Batista and H-H. Huang. 

Albert Einstein Col. of Med.

4:55   

A regulator of complex and hybrid N-glycan 

synthesis expressed mainly in testis. 

F. Batista, H-H. Huang 

and P. Stanley. Albert Einstein Col. of Med. (824.1)

5:10   

The sialyltransferase, ST3Gal4, protects 

against pressure-induced cardiac hypertrophy. 

E.S. Bennett, 

W. Deng and J. Qi. Univ. of South Florida Morsani Col. of Med. 

(595.2)

5:25 

211.3 

Homeostatic control of cell growth and 

differentiation by Golgi proofreading. 

M. Demetriou and H. 

Mkhikian. Univ. of California, Irvine.

5:50 

 

Discussion and closing remarks.

212.  THE MULTIVESICULAR BODY AND 

ENDOCYTOSIS

Symposium

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Chair’s introduction.

3:50 

212.1 

Mechanism of dynamin-catalyzed membrane 

fission. 

S.L. Schmid, S. Neumann, Y-W. Liu and J-P. Mattila. 

Univ. of Texas Southwestern Med. Ctr. and The Scripps Res. 

Inst.

4:15   

Casein kinase 1

d/ε regulates clathrin- and 

actin-mediated endocytosis.  

Y.C. Peng, A. Grassart, R. Lu, A. 

Michelot, C. Wong, J. Yate III, G. Barnes and D. Drubin. Univ. 

of California, Berkeley and The Scripps Res. Inst.

 (553.25)

4:30 

212.2 

ESCRTing receptor downregulation: 

assembly and function of the ESCRT-III complex.