Anthrax
Treatment
TR
E
AT
M
E
N
T
Acute
plus
switch to oral antibiotic therapy
Primary options
» ciprofloxacin
: 500 mg orally twice daily
OR
» moxifloxacin
: 400 mg orally once daily
OR
» levofloxacin
: 750 mg orally once daily
OR
» doxycycline
: 100 mg orally twice daily
OR
» amoxicillin
: 1000 mg orally three times daily
Secondary options
» clindamycin
: 600 mg orally three times daily
»
Patients may be switched to single-agent oral
therapy once they have completed 2 weeks
of intravenous therapy and have shown a
significant clinical response.
»
Amoxicillin should only be used if
B anthracis
is sensitive to penicillin.
»
Total duration of therapy for a severe infection
is 60 days.
[34]
adjunct
antitoxin
Primary options
» obiltoxaximab
: consult specialist for
guidance
on dose
OR
» raxibacumab
: consult specialist for
guidance on dose
OR
» anthrax immunoglobulin (human)
:
consult
specialist for guidance on dose
»
The US Centers for Disease Control and
Prevention (CDC) recommends that an antitoxin
should be added to combination antimicrobial
30
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