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Tumor Lysis Syndrome
-Usually seen as a complication of hematologic malignancies such as leukemia
-Caused by a massive release of intracellular ions and proteins causing electrolyte abnormalities and renal failure
-Most worrisome- hyperkalemia and hyperphosphatemia
First step- aggressive hydration with IV fluids
Second step (in tandem with first step)- hyperkalemia/hyperphos treatment
PEARL: Be cautious in giving calcium in these patients because it may precipitate calcium phosphate in the kidneys. Only give calcium if the patient has arrhythmia on their EKG, a widened QRS, or seizures
Other hyperkalemia treatments- beta-agonists, bicarb, insulin/glucose (also treats hyperphosphatmia), dialysis for severe cases
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