Organizing co mmittee

References: 
1.
U.Kh. 
Kurbanov, 
N.I. 
Mukarramov, 
Scientific-practical 
conference 
"Development and future of chemistry of natural compounds in Uzbekistan" 
dedicated to the 75
th
anniversary of the Faculty of Chemistry of National University 
of Uzbekistan named after M. Ulugbek May 27, 2021 TASHKENT, 26 (2021) 
2.
U.Kh. Kurbanov, A.M. Nigmatullaev, N.I. Mukarramov, "Agro inform" 
Special issue 2, 70 (2021) 
3.
U.Kh. Kurbanov, N.I. Mukarramov, A.M. Nigmatullaev, K.S. Jaunbaeva, 
Lectures of the Academy of Sciences of the Republic of Uzbekistan, 4, 56 (2022) 
N
H
3
C
O
C
O
CH
2
OH
OH
CH
3
OH
HO

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Poster presentation 
103 
CREATING OF THE COMPOSITION AND TECHNOLOGY OF 
SUPPOSITORIES BASED ON THE ESTROGEN ACTIVE 
TEFESTROL 
Sh.N. Madrakhimov
1
, S.K. Burkhonova
2
, S. F Aripova
1
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent; 
e-mail: [e-mail] 
2) Tashkent Pharmaceutical Institute 
Tefestrol (FS 42 Uz--0150-2005) is a natural mixture of esters of sesquiterpene 
alcohols and its esters the main components are ferutinin and tenuferidin, obtained from 
the roots of Ferula finely dissected White, with a cream color powder, soluble in 
chloroform, moderately soluble in 96% alcohol, and in oils (opalescence of the resulting 
solution is allowed), practically insoluble in water.
One of the important and major factors affecting the effectiveness of the drug 
substance is the suppository base. Suppository base should provide optimal structural 
and mechanical properties and one of the important indicators is the stability of 
viscoplastic systems. The base, which forms a large part of the suppository, has certain 
physical and chemical properties and a significant impact on the bioavailability of the 
active substances, the therapeutic effect, the uniformity of drug distribution, dosing 
accuracy. When conducting research as an active pharmaceutical substance was taken 
tefestrol, as a choice of carrier studied four types of base, often used in modern 
pharmaceutical production and recommended by GF v. XIII.
For the experiment, suppositories were prepared and suppository models were 
obtained with a mass of 2.5 g containing 3 mg of the active substance. Suppositories 
were prepared by pouring method due to the fact that this method is used in industrial 
conditions. Considering that. the amount of active substance in the suppositories was 
less than 5%, the substitution factor was not taken into account. The required amount of 
the base was melted in a water bath. Separately, tefestrol was pre-mixed in a porcelain 
cup with a small amount of molten base, then added to the suppository base and 
thoroughly mixed. The consistency of the molten mass at the time of pouring should be 
close to the solidification temperature. Then stirring quickly poured into pre-lubricated 
with soapy alcohol suppository forms and placed in the refrigerator for solidification. 
After 35-40 minutes the prepared suppositories were removed from the mold and 
checked for compliance with the requirements of GF XII. Ready suppository models 
were analyzed in accordance with the ND by the following criteria: description, mass 
uniformity, melting temperature, solidification temperature, average mass and 
deviations from the average mass.

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Poster presentation 
104