Organizing co mmittee

EXTRANEOUS IMPURITIES OF TENESTROL SUBSTANCE 
 
M.A. Mamatkhanova, R.M. Khalilov, A.U. Mamatkhanov
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
 
For a chromatographic study, a solvent system of hexane-ethyl acetate-ethanol was 
used, and chromatography was carried out on Silufol UV-254 plates, then viewed in 
ultraviolet light at a wavelength of 254 nm and sprayed with a solution of vanillin in 
sulfuric acid. 
In all samples of the Tenestrol substance, when applied to a chromatographic plate of 
100 μg (I), 5 spots were detected, two of which - the first and third - when sprayed with 
a solution of vanillin in sulfuric acid give a characteristic color: green, turning into blue 
(ferutinin), and pinkish-violet (tenuferidine). 
When applying 1.25 μg (II), no more than two main spots were found, when sprayed 
with a solution of vanillin in sulfuric acid, ferutinin dyed green, turning into blue; 
tenuferidine does not form a characteristic stain.
When applying 15 μg (III)of the substances were observed 4 spots: two main spots 
(first and third) - ferutinin and tenuferidin, which, when sprayed with a solution of 
vanillin in sulfuric acid, give a characteristic stain, the second spot - 4β-hydroxy-6α -β-
hydroxybenzoyloxy-10α-angeloyloxy-dauk-8-ene and the fourth spot is a substance of 
undetermined structure (Fig.). 
 
Fig. Thin layer chromatography of Tenestrol substance 

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Poster presentation 
115 
ABOUT THE PRODUCTION TECHNOLOGY OF THE DRUG 
SUBSTANCE GALANTHAMINE HYDROBROMIDE 
 
Sh.R. Nigmanova, R.A. Botirov, A.Z. Sadikov, Sh.Sh. Sagdullaev
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
In our institute, industrial production technology of galantamine hydrobromide 
medicinal substance with anticholinesterase properties from the leaves of Victor's sedge 
plant was created and put into practice for serial production [1,2]. The medical 
requirements of our country are fully satisfied with the drug, and the substance is