Organizing co mmittee

References: 
[1] Oliveira, DR; et al. Estudo etnofarmacognóstico da saracuramirá (
Ampelozizyphus 
amazonicus
Ducke), uma planta medicinal usada por comunidades quilombolas do Município 
de Oriximiná-PA, Brasil. 
Acta Amazonica
, v. 41, 2011. 
[2] Peçanha, LMT; et al.,Immunobiologic and Antiinflammatory Properties of a Bark Extract 
from 
Ampelozizyphus amazonicus
Ducke. 
Journal of Biomedicine and Biotechnology
, (2013), 1-
11, 2013. 
[3] Simen, TJM; et al., Spray-dried extract from the Amazonian adaptogenic plant 
Ampelozizyphus 
amazonicus
Ducke 
(Saracura-mirá): 
Chemical composition and 
immunomodulatory properties. 
Food Research International
, v. 90, p. 100-110, 2016. 
[4] Figueiredo F.S.; et al. Countercurrent chromatography separation of saponins by 
skeleton type from 
Ampelozizyphus amazonicus 
by off-line ultra-high-performance liquid 
chromatography/high resolution accurate mass spectrometry analysis and characterization. 
Journal of Chromatography A
, v.1481, p. 92-100, 2016. 

---

Plenary presentation 
12 
TARGETED SYNTHESIS AND MODIFICATIONS OF 
QUINAZOLINE ALKALOIDS AND THEIR ANALOGUES 
A.U. Berdiev, U.M. Yakubov, B.Zh. Elmuradov* 
Institute of the Chemistry of Plant Substances, Academy of Sciences, Republic of 
Uzbekistan, 100170, Tashkent, Mirzo-Ulugbek str., 77. 
*E-mail: [e-mail]  
Quinazolines are considered an attractive target for medicinal chemists, because they 
are the scaffold of several potent antitumor drugs. Leading examples are the well-
known 
erlotinib
and 
gefitinib
. There are among of the new annelated imidazoles and 
pyrimidines some highly effective compounds, which were selected by the National 
Cancer Institute (NCI) for the treatment of different types of human cancer cell lines, 
also useful lead compounds in the search for powerful dual anticancer-antimicrobial 
agents. Some benzopyrimidines possessed remarkable broad-spectrum antitumor 
activity which was almost fifteen-fold more active than the known drug 5-fluorouracil 
[1-3]. In this present work, targeted synthesis and modifications of quinazoline alkaloids 
(