Organizing co mmittee

Acknowledgment: 
This study was financially supported by the Scientific Research Project Unit 
of Gaziantep University, Gaziantep-Türkiye (Project code no: TF.HZP.22.62). 

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Plenary presentation 
14 
THE TECHNOLOGY OF PRODUCING THE SUBSTANCE OF 
DRUGS BASED ON DITERPENE ALKALOIDS 
A.Z. Sadikov, Sh.Sh. Sagdullaev 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent, Uzbekistan 
Alkaloids are products of the metabolism of amino acids of protein substances of 
plants and are one of the first compounds of plant origin that drew the attention of 
pharmacologists to create therapeutic agents based on them. Based on plant alkaloids 
over the past century, hundreds of preparations, bioreagents for medicine and the needs 
of the national economy have been created. 
For many years, our Institute has been conducting research work on the isolation, 
chemical study of isolated substances, proof of the structure, work is underway to study 
biological activity and toxicity, industrial technologies for obtaining substances of 
biologically active drugs, bioreagents, etc., are being developed on the basis of 
alkaloids. To date, dozens of drugs based on alkaloids have been created and introduced 
into medical practice. As a result of many years of research by chemists and 
pharmacologists of our Institute, dozens of diterpene alkaloids from plant raw materials 
have been isolated from plants, and their biological activities have been studied. New, 
original drugs with antiarrhythmic action have been created, such as Allapinin, Aklezin, 
Aksaritmin, 
Antiarrhythmin, 
Dihydroathezine 
hydrochloride, 
Benzoraphin, 
Benzoylnapellin hydrochloride, high purity Akonitin bioreagent, etc. Currently, highly 
efficient industrial technologies for the production of the substance of the above drugs 
have been developed. 
Due to the increasing requirements for the quality of active pharmaceutical 
ingredients, the variety of production equipment, and also given the sometimes-sharp 
price changes for various organic solvents used in the production of allapinin, various 
problems arise in the production of this drug. Therefore, several technological methods 
for the production of this drug have been developed, taking into account current 
economic and other conditions: 
1.
Method for the production of allapinin by extraction of plant materials with 
organic solvents under alkaline conditions; 
2.
The production of allapinin by extraction of plant materials with weak solutions 
of organic acids with further purification of the extract by ion exchange; 
3.
The production of allapinin by extraction of plant materials with weak solutions 
of organic acids with further purification of the extract by liquid-liquid extraction; 
4.
Method for the production of allapinin by extraction of plant materials with ethyl 
alcohol solutions with further purification; 
5.
Method for the production of allapinin by extraction of plant materials with 
weak acid solutions and purification of the extract by ultrafiltration. 
6.
The substance obtained by the above methods in terms of qualitative and 
quantitative indicators fully meets the requirements of the FS for the drug. 
Currently, research work is underway to develop alternative new technological 
methods for obtaining the substance of drugs based on diterpene alkaloids, such as 
Aklesin, Aksaritmin, Antiarrhythmin, Benzoylnapelin hydrochloride, Dihydroatezine 
hydrochloride, etc. 

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Plenary presentation
15