Organizing co mmittee

SYNTHESIS OF THE NOVEL HYDRAZONES BASED ON
2-HYDRAZINOBENZOXAZOLES AND THEIR INHIBITION 
ACTIVITY 
 
Z.J. Pulatova, I.S. Ortikov, B.J. Elmuradov
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail]  
 
One of the important issues today is the easy synthesis of potentially active 
heterocyclic compounds, and the search among them for less toxic, pharmacologically 
active compounds, and the targeted synthesis of promising substances, as well as the 
creation of effective drugs based on them. Among such active heterocyclic compounds, 
we can cite 2-hydrazinobenzoxazole (
2
) and its derivatives as examples. Many of their 
derivatives are potentially biologically active substances and are being synthesized as 
anti-inflammatory, anti-diabetic, anti-cancer agents [1,2]. Compound 
2
can be easyly 
obtained (
i
) from 2-mercapto-benzoxazole (
1
) and hydrazine hydrate: 
Information on the synthesis of 2-hydrazinobenzoxazole derivatives can be found in 
the literature, but we can see that in most of them, the yield of the products is very low, 
or the reaction conditions are very difficult. Therefore, the development of easy and 
convenient methods of synthesis of this class of compounds is very relevant from the 
point of view of both theoretical and practical organic chemistry. Reactions with some 
substituted aromatic aldehydes (
ii
) based on 2-hydrazinobenzoxazole (
2
) were carried 
out under solvent and catalyst-free conditions. As a result, corresponding hydrazones 
(
3-6
) were obtained in good yields. The synthesized hydrazones possess good inhibition 
activity. 
The structure of the synthesized substances was proved based on the results of IR-, 
1
H and 
13
C NMR spectroscopies. 
References
1.
Hemalatha Gadegoni, Sarangapani Manda, and Shivaprasad Rangu. 
Journal of the 
Korean Chemical Society
2013, Vol 57, No.2.
2.
Avinash Patil, Swastika Ganguly, Sanjay Surana. 
Rasayan Journal of Chemistry
, 
2008, Vol.1, №3, P.447-460. 
 

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Poster presentation 
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