Organizing co mmittee

SYNTHESIS AND CRYSTAL STRUCTURE OF INTERACTION 
PRODUCTS OF 2-METHOXYCARBONYLAMINO-
BENZIMIDAZOLE AND PROPIONIC ACID 
 
S.S. Saidov,
1
 В.I. Avazova,
2
 A.Sh. Abdurazakov,
1
 R.Ya. Okmanov
1
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
2) Urgench State University. Kh. Alimdjan str., 14, Urgench city, 220100, 
Uzbekistan 
Previously, we studied the reactions of 2-methoxycarbonylaminobenzimidazole (
1
) 
with benzoic acid. The reaction was carried out by boiling equimolar amounts of 
reagents, dimethylformamide was used as a solvent. As a result of the reaction, 2-
benzoylaminobenzimidazole and a salt of 2-aminobenzimidazole with benzoic acid 
were obtained [1]. Continuing similar studies, the interaction of the initial 2-
methoxycarbonylaminobenzimidazole with aliphatic - propionic acid was studied, 
propionic acid was used in excess as a reagent and solvent to obtain products 2-
propionylaminobenzimidazole (
2
) and salt of 2-aminobenzimidazole with propionic 
acid (
3
) with a yield of 42.4%, 53.6% respectively.
For reliable refinement of the structure, X-ray structural analysis was performed.
2 
 
 
 
 
3 
Figure 1. Molecular structures of the compounds 2 and 3, including atom labelling. 
Intramolecular H-bond is shown with dashes lines 
 
Reference 
1. A.Sh. Abdurazakov, S.S. Saidov, R.Ya. Okmanov, Sh.Kh. Kubaev, B.Zh. 
Elmuradov. 
Egypt. J. Chem. 
2021, Vol. 64, No. 5 pp. 2247 – 2252. 
N
H
OCH
3
N
N
H
O
N
N
N
H
H
O
C
2
H
5
N
+
NH
2
N
H
H
+
O
–
O
C
2
H
5
C
2
H
5
COOH