Organizing co mmittee

 
 

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Poster presentation 
223 
BIOLOGICAL ACTIVITY 2-ALKYLTHIO-5-AMINO-1,3,4-
THIADIAZOLES 
P.A. Nurmakhmadova, T.Т. Toshmurodov, S.M. Turaeva, A.А. Ziyaev 
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
At present to obtain high and stable yields, the use of highly effective insecticides to 
protect crops from insect pests is a necessary condition. Due to the constant resistance 
of insects to the insecticides used, their assortment has to be regularly updated and 
preparations with a specific mode of action for insects are used. [1]. 
It is known from the literature that 1,3,4-thiadiazole derivatives have a different 
spectrum of biological activity. Among the representatives of the thiadiazole series, 
compounds are exhibiting antimicrobial, antifungal, antiviral, antitumor, herbicidal, and 
insecticidal activity [2]. 
The apple aphid (
Aphis pomi
) is a member of the aphid family (
Aphidae
). 
Aphis pomi
damages apple, pear, quince, hawthorn, mountain ash, and many other crops. Aphids 
pierce leaves, buds, shoots, and ovaries with their proboscis, very rarely fruits, and suck 
out the juice, which leads to twisting of leaves and shoots, deformation and death, small 
fruit, and deterioration of the general condition of trees. 
Successful control and improvement of measures to protect the apple tree from this 
pest is possible only based on experimental data on the characteristics of the life cycle, 
economic importance in specific conditions, and the use of new means of control. 
In this regard, the study of the insecticidal activity of 1,3,4-thiadiazole derivatives is 
of interest for the creation of new effective insecticidal preparations against sucking 
pests such as aphids, thrips, whiteflies, etc. 
The insecticidal activity of the synthesized 2 alkylthio-5-amino-1,3,4-thiadiazoles 
was studied under laboratory conditions against the 
Aphis pomi
. The systemic 
insecticide Karbofos 50% e.c. was chosen as a reference. (a.s. malathion). 
According to the results of laboratory screening, it was found that substances T-1, T-
2, T-3, T-4, T-8, and T-10 in all (0.1, 0.01, and 0.001%) concentrations are highly toxic 
(90.0% - 100%) for adults 
Aphis pomi
. The lowest efficiency (13.3%-50.0%) was 
observed during incubation with substances T-4, T-5, T-6, T-9, T-11, T-13 at doses of 
0.1, 0.01 and 0.001%. In the reference variant, the mortality of 
Aphis pomi
reached 
90.0%, and in the control variant, the mortality of 
Aphis pomi
was not detected.