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Poster presentation 
240 
SYNTHESIS OF NEW 1,2,3-TRIAZOLE DERIVATIVES BASED ON 
OXALIC ACID DIPROPARGYL ESTER 
 
N.G. Nurillaeva,
1,2 
I.S. Ortikov,
1,3 
Zh.U. Bobokhuzhaev
2
, I.A. Abdugafurov
2 
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
2) National University of Uzbekistan. 
3) Chirchik State Pedagogical University of Tashkent region 
Nowadays, 1H-1,2,3-triazoles are the most studied compounds, and in recent years, 
articles of this class have been published in prestigious journals. The main reasons for 
this are the novelty and convenience of the synthesis method, high pharmacological 
activity, and low toxicity. At present, reactions going through azide and alkyne 
cycloaddition are also used in polymeric materials [1]. Among 1,2,3-triazoles, there are 
many preparations with herbicidal, fungicidal, insecticidal activity; there are many 
substances with anti-inflammatory, anti-diabetic, anti-microbial activity [2]. Therefore, 
it is very important to synthesize new derivatives of 1,2,3-triazoles, to determine their 
structure and biological activity. 
It is known that synthesis of 1,2,3-triazole derivatives based on aliphatic 
monocarboxylic acid propargyl ethers has been studied in detail [3]. However, the 
synthesis of 1,2,3-triazoles based on saturated dicarboxylic acid dipropargyl ethers has 
not been studied in detail. In our research work, we conducted experiments based on 
oxalic acid, the first representative of dicarboxylic acids. First, dipropargyl oxalate (