Organizing co mmittee

1
:R-X:KOH - 1:1.2:2 at 
the 78
0
C for 6 hours, and 2,6,8-trimethyl-3-alkylquinazoline-4(3H)-ones (
2-6
) were 
synthesized in good yields (76-82%).
It should be noted that the yield of alkylation products (
2-6
) is much higher, and with 
the increase of the alkyl chain, a decrease in the melting points of compounds are 
observed. This is an important property in homologous series of organic compounds. 
The structure of the synthesized compounds (
2-6
) was proved by IR and NMR 
spectra. 
References 
1. Chang M., Mobashery S., Bouley R. 
US Patent
20,160,031,832, 2016. 
2. Tiwary B. K., Pradhan K., Nanda A. K., Chakraborty R. 
Journal of Chemical 
Biology & Therapeutics. 
2015; 1, article 104
3. Sharma K., Khandelwal S., Samarth R. M., Kumar M. 
Journal of Heterocyclic 
Chemistry.
2016; 53(1):220–228.
4. Nerkar A. G., Sahu M., Valvi S., Sawant S. D. 
Journal of Young Pharmacists
. 
2015; 7(4):303–310.

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Poster presentation 
248 
SYNTHESIS OF TARGETED SULFONYLUREAS IN THE 
SERIES OF BICYCLIC 3-ALKYLQUINAZOLONES 
 
S. M. Allabergenova, U. M. Yakubov, B. J. Elmuradov
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of the 
Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
e-mail: [e-mail] 
It is known that many harmless, highly active synthetic drugs are being developed in 
the fields of agriculture and pharmacology. Among of them, the active substances, 
which are necessary for industry, agriculture and pharmaceuticals, derivatives of 
substituted urea and sulfonylureas containing various functional groups are found. Its 
derivatives are used in industry as paints, corrosion inhibitors, selective herbicides, 
fungicides in agriculture, organocatalysts in petrochemicals. 
Nowadays, the use of chemical protection agents in agriculture is increasing. The 
global market share of agrochemicals is worth 60 billion dollars a year and continues to 
grow. Herbicides take the largest share, 40-60% in different parts of the world, 
depending on crop dominance. Sulphonylureas are the class of herbicides with the 
highest biological activity. Chlorsulfron, the first representative of this class of 
compounds, was produced by the DuPont company in 1982. The use of sulfonylureas in 
low doses (10-100 g/ha), high selectivity, and safety for humans and animals increase 
the demand for compounds of this class. Therefore, it is very urgent to carry out 
targeted synthesis and chemical modification of new, potentially biologically active 
compounds containing sulfonylurea residues, to determine their physical, chemical and 
biological properties, to create new preparations based on selected candidate substances. 
It is known from the literature [1], that there are various methods of synthesizing 
sulfonylureas, one of which is the reaction of compounds containing a sulfonamide 
group with isocyanates. Therefore, we studied interaction of 3-methyl-4-oxo-3,4-
dihydroquinazoline-6-sulfonamide 
(
1
) 
with 
o
-, 
m
-tolylisocyanates 
and 
1-
naphthylisocyanate in acetone in the presence of potash and synthesized novel 
corresponding sulfonylureas (