Organizing co mmittee

ALKYLATION REACTIONS OF QUINAZOLIN
-
4
-
ONE 
DERIVATIVES 
 
R.K. Karimov
1
,
 
A.Sh. Abdurazakov
1
, M.E. Ziyadullaev
2
, A.А. Gapparova
2
. 
 
1) S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences of 
the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent 
2) Chirchik State Pedagogical University 111700, Tashkent region, Chirchik, Amir 
Temur Street, 104,
 
Uzbekistan 
Scientific research aimed at synthesizing quinazolin-4-one alkaloid and its 
derivatives, creating production technologies and expanding the fields of application is 
being carried out in leading scientific centers and laboratories of the world [1-2].
As a result of the research carried out in this direction, the synthesis of the 
quinazolin-4-one compound and its various substituted derivatives, as well as the 
scientific literature on their biological activity were analyzed, and the following 
alkylation reactions were carried out based on them. 
Usually alkyl halides, alkenes, epoxy compounds, alcohols, aldehydes, ketones, 
ethers, sulfides, diazoalkanes can be included. Bases, mineral acids, Lewis acids and 
zeolites are used as alkylation catalysts. Alkylation reactions of quinazolin-4-ones can 
be carried out on two reaction centers, i.e., on the nitrogen atom in the position 3 or the 
oxygen atom in the position 4. 
It is known that the alkylation of substituted quinazolin-4-one and its various 
aliphatic and aromatic halogen ketones and the presence of potassium carbonate in the 
DMF medium at temperatures from 40
o
C to 130
o
С lead to the formation of quinazoline 
ketones. 
The IR, 
1
H, 
13
C NMR spectra of the synthesized compounds were studied, and 
scientific research is being conducted on their biological activity against various 
bacterial strains. 
References 
1.
Glowacka I.E., Balzarini J., Wroblewski A.E. The synthesis, antiviral, cytostatic 
and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-
triazole linker // J. Med. Chem. 2013. Volume 29, No. 15. pp. 157-163. 
2.
Desai N.C., Amit Dodiya., Niraj Shihori. Synthesis and antimicrobial activity of 
novel quinazolinone-thiazolidine-quinoline compounds // Journal of Saudi Chemical 
Society, 2013. Volume 17, No 5. pp. 259-267. 

---

Poster presentation 
260