Microsoft Word search phase 3 Title Page Amendment

Diab.Care 2003;26:2876-82. 
70.
 
Wilkin TJ. The accelerator hypothesis: weight gain as the missing link between Type I and 
Type II diabetes. Diabetologia 2001;44:914-22. 
71.
 
Larsson HE, Hansson G, Carlsson A, Cederwall E, Jonsson B, Jönsson B,  Larsson K, 
Lynch K, Neiderud J, Lernmark A, Ivarsson SA; DiPiS Study Group. Children developing 
type 1 diabetes before 6 years of age have increased linear growth independent of HLA 
genotypes. Diabetologia 2008;51:1623-30. 
72.
 
Lamb MM, Yin X, Zerbe GO, Klingensmith GJ, Dabelea D, Fingerlin TE, Rewers M, 
Norris JM. Height growth velocity, islet autoimmunity and type 1 diabetes development: the 
Diabetes Autoimmunity Study in the Young. Diabetologia 2009;52:2064-71. 
73.
 
Knerr I, Wolf J, Reinehr T, Stachow R, Grabert M, Schober E, Rascher W, Holl RW; DPV 
Scientific Initiative of Germany and Austria. The 'accelerator hypothesis': relationship 
between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 
German and Austrian children with type 1 diabetes mellitus. Diabetologia 2005;48:2501-4. 
74.
 
Betts P, Mulligan J, Ward P, Smith B, Wilkin T. Increasing body weight predicts the earlier 
onset of insulin-dependent diabetes in childhood: testing the 'accelerator hypothesis. 
Diabetic Med. 2005;22:144-51. 
75.
 
Couper JJ, Beresford S, Hirte C, Baghurst PA, Pollard A, Tait BD, Harrison LC, Colman 
PG. Weight gain in early life predicts risk of islet autoimmunity in children with a first-
degree relative with type 1 diabetes. Diab.Care 2009;32:94-9. 
76.
 
Dabelea D, Pettitt DJ, Jones KL, Arslanian SA. Type 2 diabetes mellitus in minority 
children and adolescents. An emerging problem. [Endocrinology & Metabolism Clinics of 
North America /9;28:709-29. 
77.
 
Kitagawa T, Mano T, Fujita H. The epidemiology of childhood diabetes mellitus in Tokyo 
metropolitan area. Tohoku J.exp.Med. 1983;141 Suppl:171-9:171-9. 
78.
 
Dabelea D, Hanson RL, Bennett PH, Roumain J, Knowler WC, Pettitt DJ. Increasing 
prevalence of Type II diabetes in American Indian children. Diabetologia 1998;41:904-10. 
79.
 
Scott CR, Smith JM, Cradock MM, Pihoker C. Characteristics of youth-onset noninsulin-
dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis. Pediatrics 
1997;100:84-91. 
80.
 
Lipton R, Keenan H, Onyemere KU, Freels S. Incidence and onset features of diabetes in 
African-American and Latino children in Chicago, 1985-1994. Diabetes/Metabolism 
Research Reviews.2002; 18:135-42 

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Section 4A - Study Objectives/Background and Significance (Phase 3 - 11/2010) 
Section 4A - Page 21 
 Registry 
Study
 
 
81.
 
Pinhas-Hamiel O, Dolan LM, Zeitler PS. Diabetic ketoacidosis among obese African-
American adolescents with NIDDM. Diab.Care 1997;20:484-6. 
82.
 
Macaluso CJ, Bauer UE, Deeb LC, Malone JI, Chaudhari M, Silverstein J, Eidson M, 
Goldberg RB, Gaughan-Bailey B, Brooks RG, Rosenbloom AL. Type 2 diabetes mellitus 
among Florida children and adolescents, 1994 through 1998. Public Health Rep. 
2002;117:373-9. 
83.
 
Likitmaskul S, Kiattisathavee P, Chaichanwatanakul K, Punnakanta L, Angsusingha K, 
Tuchinda C. Increasing prevalence of type 2 diabetes mellitus in Thai children and 
adolescents associated with increasing prevalence of obesity. Journal of Pediatric 
Endocrinology & Metabolism 2003;16:71-7. 
84.
 
Haines L, Wan KC, Lynn R, Barrett TG, Shield JP. Rising incidence of type 2 diabetes in 
children in the U.K. Diab.Care 2007;30:1097-101. 
85.
 
McMahon SK, Haynes A, Ratnam N, Grant MT, Carne CL, Jones TW. Increase in type 2 
diabetes in children and adolescents in Western Australia. Med J Aust 2004;180:459-61. 
86.
 
Dean HJ, Young TK, Flett B, Wood-Steiman P. Screening for type-2 diabetes in aboriginal 
children in northern Canada. Lancet 1998;352:1523-4. 
87.
 
Harris SB, Gittelsohn J, Hanley A, Barnie A, Wolever TM, Gao J, Logan A, Zinman B. The 
prevalence of NIDDM and associated risk factors in native Canadians. Diab.Care 
1997;20:185-7. 
88.
 
Schober E, Holl RW, Grabert M, Thon A, Rami B, Kapellen T, Seewi O, Reinehr T. 
Diabetes mellitus type 2 in childhood and adolescence in Germany and parts of Austria. Eur 
J Pediatr 2005;164:705-7. 
89.
 
Ortega-Rodriguez E, Levy-Marchal C, Tubiana N, Czernichow P, Polak M. Emergence of 
type 2 diabetes in an hospital based cohort of children with diabetes mellitus. Diabetes 
Metab 2001;27:574-8. 
90.
 
Feltbower RG, McKinney PA, Campbell FM, Stephenson CR, Bodansky HJ. Type 2 and 
other forms of diabetes in 0-30 year olds: a hospital based study in Leeds, UK. Arch Dis 
Child 2003;88:676-9. 
91.
 
Ehtisham S, Barrett TG, Shaw NJ. Type 2 diabetes mellitus in UK children – an emerging 
problem. Diabetic Med. 2000;17:867-71. 
92.
 
Rami B, Schober E, Nachbauer E, Waldhor T. Type 2 diabetes mellitus is rare but not 
absent in children under 15 years of age in Austria. Eur J Pediatr 2003;162:850-2. 
93.
 
Thomas DB. Alternatives to a national system of population-based state cancer registries. 
Am J Public Health 2002;92:1064-6. 

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Section 4A - Study Objectives/Background and Significance (Phase 3 - 11/2010) 
Section 4A - Page 22 
 Registry 
Study
 
 
94.
 
Laing SP, Swerdlow AJ, Slater SD, Botha JL, Burden AC, Waugh NR, Smith AW, Hill RD, 
Bingley PJ, Patterson CC, Qiao Z, Keen H. The British Diabetic Association Cohort Study, 
I: all-cause mortality in patients with insulin-treated diabetes mellitus. Diabet Med 1999 
Jun;16(6):459-65. 
95.
 
Bruno G, Cerutti F, Merletti F, Novelli G, Panero F, Zucco C, Cavallo-Perin P. Short-term 
mortality risk in children and young adults with type 1 diabetes: the population-based 
Registry of the Province of Turin, Italy. Nutr Metab Cardiovasc Dis 2009 Jun;19(5):340-4. 
96.
 
Skrivarhaug T, Bangstad HJ, Stene LC, Sandvik L, Hanssen KF, Joner G. Long-term 
mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway. 
Diabetologia 2006 Feb;49(2):298-305. 
97.
 
Waernbaum I, Blohme G, Ostman J, Sundkvist G, Eriksson JW, Arnqvist HJ, Bolinder J, 
Nystrom L. Excess mortality in incident cases of diabetes mellitus aged 15 to 34 years at 
diagnosis: a population-based study (DISS) in Sweden. Diabetologia 2006 Apr;49(4):653-9. 
98.
 
Dahlquist G, Kallen B. Mortality in childhood-onset type 1 diabetes: a population-based 
study. Diabetes Care 2005 Oct;28(10):2384-7. 
99.
 
Podar T, Solntsev A, Reunanen A, Urbonaite B, Zalinkevicius R, Karvonen M, LaPorte RE, 
Tuomilehto J. Mortality in patients with childhood-onset type 1 diabetes in Finland, Estonia, 
and Lithuania: follow-up of nationwide cohorts. Diabetes Care 2000 Mar;23(3):290-4. 
100.
 
Burnet DL, Cooper AJ, Drum ML, Lipton RB. Risk factors for mortality in a diverse cohort 
of patients with childhood-onset diabetes in Chicago. Diabetes Care 2007 Oct;30(10):2559-
63. 
101.
 
Pavkov ME, Bennett PH, Knowler WC, Krakoff J, Sievers ML, Nelson RG. Effect of youth-
onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young 
and middle-aged Pima Indians. JAMA 2006 Jul 26;296(4):421-6. 

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Study Objectives & Background and Significance 
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