60% of the population eventually become infected. In some developing countries, the figure is up to 95%.
Defined as the isolation of CMV from the saliva or urine within 3 weeks of birth.
Commonest congenital viral infection, affects 0.3 - 1% of all live births. The second most common cause of mental handicap after Down's syndrome and is responsible for more cases of congenital damage than rubella.
Transmission to the fetus may occur following primary or recurrent CMV infection. 40% chance of transmission to the fetus following a primary infection.
May be transmitted to the fetus during all stages of pregnancy.
No evidence of teratogenecity, damage to the fetus results from destruction of target cells once they are formed.