A.C.G. Dos Santos,
S. Jonnalagadda and D. Gallaher. Univ. of Minnesota, St. Paul
and Gen. Mills, Golden Valley MN.
3:15
371.2
Bone protective effects of dried plum is through
increasing osteoprotegerin and suppressing sclerostin levels.
S. Hooshmand, J. Brisco, M. Elam, S.C. Chai and B.H.
Arjmandi. San Diego State Univ., Florida State Univ. and Univ.
of North Carolina at Chapel Hill.
3:30
371.3
Lipolytic effect of olive leaf extracts and a major
component on mature 3T3-L1 cells.
S-J. Ryu, H-S. Choi, O-H.
Lee and B-Y. Lee. CHA Univ. and Kangwon Natl. Univ., South
Korea.
3:45
371.4
Low-glycemic index diets prevent type 2
diabetes in the Nile rat.
J. Bolsinger, A. Pronczuk and K.C.
Hayes. Brandeis Univ.
TUESDAY NUTRITION
102
4:00
371.5
Black soybean may be effective to recover the
impaired insulin signaling in high cholesterol diet-induced non-
alcoholic fatty liver disease mice model.
J-H. Jung, L-N. Yoon
and H-S. Kim. Sookmyung Women’s Univ., South Korea.
4:15
371.6
Date seed powder-containing bread exhibits
higher levels of flavonoids and antioxidant capacity compared
to regular and whole wheat bread.
C. Platat, H.M. Habib, W.H.
Ibrahim, I.B. Hashim and A.K. Eldin. Col. of Food and Agr.,
United Arab Emirates Univ.
4:30
371.7
Botanicals inhibit castrate-resistant prostate
cancer via mechanisms involving AMPK, inhibition of
lipogenesis, mTOR-mediated proliferation, and histone
modification.
Y. Zhao and J. Whelan. Univ. of Tennessee
Knoxville.
4:45
371.8
Compound K, a Panax ginseng saponin,
inhibits lipid accumulation during adipocyte differentiation by
regulating early adipogenic genes.
H-J. Jeon and H-S. Choi.
CHA Univ., South Korea.
372. DIET AND CANCER: TRANSLATIONAL,
CLINICAL AND SURVIVORSHIP
Minisymposium
(Sponsored by: Diet and Cancer RIS)
t
ue
. 3:00
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 156B
C
haired
: J. W
helan
C
oChaired
: e. C
ho
3:00
372.1
Fruit and vegetable intake and bladder cancer
risk: the Multiethnic Cohort Study.
S-Y. Park, N.J. Ollberding,
C.G. Woolcott, L.R. Wilkens, B.E. Henderson and L.N.
Kolonel. Univ. of Hawaii Cancer Ctr., Univ. of Chicago,
Dalhousie Univ., Canada and Univ. of Southern California.
3:15
372.2
The environment of phytonutrients may
contribute to their bioefficacy against cancer.
Y. Zhao and J.
Whelan. Univ. of Tennessee Knoxville.
3:30
372.3
Bone loss during hematopoietic cell
transplantation in children.
L.J. Bechard, H.A. Feldman, K.
Gura, R. Venick, E.C. Guinan, C. Gordon and C. Duggan.
Boston Children’s Hosp., UCLA Mattel Children’s Hosp., Dana-
Farber Cancer Inst. and Hasbro Children’s Hosp., Providence.
3:45
372.4
Linking obesity with colorectal polyp risk.
S.S. Comstock, K. Hortos, B. Kovan, S. McCaskey, D.R.
Pathak and J.I. Fenton. Michigan State Univ. and Tri-County
Gastroenterol. P.C., Clinton Township.
4:00
372.5
FADS genotype affects change in fatty acid
levels after a Mediterranean dietary intervention.
Z. Djuric,
S. Porenta, J. Ren, Y-A. Ko, A. Baylin, B. Mukherjee and S.
Gruber. Univ. of Michigan and Univ. of Southern California.
4:15
372.6
Leptin as a marker of undernutrition in breast
cancer recurrence.
J-M. Bard, A. Lefrançois, I. Jaffre, M-P.
Joalland, J-M. Classe, M. Campone and C. Bobin-Dubigeon.
West Cancer Inst., Ctr. René Gauducheau, St. Herblain, Univ.
of Nantes and Cancer Inst. Nantes-Angers INSERM U892,
France.
4:30
372.7
Post-diagnosis diet quality and colorectal
cancer survival.
R. Kashambwa, S. Chiuve, J. Meyerhardt,
K. Sato, F. Hu and T. Fung. Harvard Sch. of Publ. Hlth., Dana-
Farber Cancer Inst. and Simmons Col.
4:45
372.8
Characterization and stability of dietary
patterns in the year following head and neck cancer diagnosis.
A.E. Arthur, K.E. Peterson, J.R. Hebert, D.B. Chepeha, S.A.
Duffy, E.L. Bellile, J.M.G. Taylor, G.T. Wolf and L.S. Rozek.
Univ. of Michigan and Univ. of South Carolina.
373. LIPID AND FATTY ACID METABOLISM AND
TRANSPORT
Minisymposium
(Sponsored by: Energy & Macronutrient Metabolism RIS)
t
ue
. 3:00
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 156C
C
haired
: m.C. h
uanG
C
oChaired
: C. l
ammi
-K
eeFe
3:00
373.1
Dynamic regulation of hepatic vitamin E
secretion by the
a-tocopherol transfer protein. S. Chung, V.
Thakur, J. Atkinson, R. Parker and D. Manor. Case Western
Reserve Univ., Brock Univ., Canada and Cornell Univ.
3:15
373.2
Plant sterol whole body pool size in
sitosterolemia is modulated by ezetimibe.
R.A. Othman, S.B.
Myrie, D. Mymin, L. Merkens, J-B. Roullet, R.D. Steiner and
P.J.H. Jones. Univ. of Manitoba and Oregon Hlth. & Sci. Univ.
3:30
373.3
Branched chain fatty acids (BCFA)
concentrations in U.S. foods and estimated BCFA intake in the
U.S. population.
R.R. Ran-Ressler, S.E. Bae, P. Lawrence
and J.T. Brenna. Cornell Univ.
3:45
373.4
The low level of EPA in brain phospholipids
is maintained by multiple compensatory mechanisms.
C.T-H.
Chen, A.F. Domenichiello, M-O. Trepanier, Z. Liu, M. Masoodi
and R.P. Bazinet. Univ. of Toronto and Nestlé Inst. of Hlth. Sci.,
Lausanne.
4:00
373.5
Fatty acid transport protein 1 mediates
macrophage eicosanoid metabolism.
Y. Qin, A.J. Freemerman,
L. Li, R. Coleman, J. Galanko, M. Edin, D. Zeldin, A. Stahl
and L. Makowski. Univ. of North Carolina at Chapel Hill,
NIEHS, NIH, Research Triangle Park and Univ. of California,
Berkeley.
4:15
373.6
The P2Y2 receptor mediates uptake of matrix-
retained and aggregated low-density lipoprotein in primary
smooth muscle cells.
T. Dissmore, L. Mamedova, D. Medeiros
and G.A. Weisman. Kansas State Univ. and Univ. of Missouri-
Kansas City and Univ. of Missouri-Columbia.
4:30
373.7
High-fat diet alters serum fatty acid profiles in
obesity-prone rats: implications for in vitro studies.
T-W. Liu,
T.D. Heden, A. Blandon, E.M. Morris, K.L. Fritsche and J.P.
Thyfault. Univ. of Missouri-Columbia.
4:45
373.8
Leptin increases adipose triglyceride lipase in
bovine primary adipocytes.
D. Koltes and D. Spurlock. Iowa
State Univ.
NUTRITION TUESDAY
103
T
U
E
374. BRANCHED-CHAIN AMINO ACIDS IN OBESITY
AND INSULIN-RESISTANCE: FRIEND OR FOE?
Symposium
(Sponsored by: APS Endocrinology and Metabolism
Section)
(Cosponsored by: The American Society for Nutrition,
Energy and Macronutrient Metabolism RIS)
t
ue
. 3:15
pm
—B
oston
C
onvention
& e
xhiBition
C
enter
, 206a
C
haired
: t.G. a
nthony
C
oChaired
: s. a
Dams
3:15
Introduction and overview.
T. G. Anthony. Rutgers Univ.
3:25
Branched chain amino acids in diabetes and insulin
resistance: chicken, egg, or red herring?
S. Adams.
USDA, Davis.
3:45
Regulation of branched-chain amino acid catabolism by
type 2 diabetes.
Y. Shimomura. Nagoya Univ.
4:15
Protein and BCAA metabolism in obesity.
C. Lynch.
Penn State Col. of Med.
4:45
Metabolic roles of branched-chain amino acids in the
treatment of obesity.
D. K. Layman. Univ. of Illinois at
Urbana-Champaign.
Pathology
375. JOURNAL OF HISTOCHEMISTRY AND
CYTOCHEMISTRY PLENARY LECTURE
Lecture
(Sponsored by: The Histochemical Society)
t
ue
. 8:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 162a
C
haired
: J.r. C
ouChman
Vascular Biology
Stem Cells
8:30 Introduction.
8:35
How vascular endothelial growth factor regulates
differentiation of mesenchymal stem cells.
B. R.
Olsen. Harvard Med. Sch.
376. HIGH SCHOOL TEACHERS SESSION:
SCIENTIFIC SLEUTHING OF HUMAN DISEASE
FOR HIGH SCHOOL TEACHERS
Special Session
(Sponsored by: ASIP Education Committee and
Intersociety Council on Pathology Information)
t
ue
. 8:30
am
—W
estin
B
oston
W
aterFront
h
otel
, D
ouGlas
C
haired
: m.B. F
urie
anD
K.n
eJaK
-B
oWen
8:30
Check-in and continental breakfast.
9:10
Welcome and introduction.
M. E. Sobel. ASIP.
9:30
Menacing microbes: the threat of bioterrorism.
M. B.
Furie. Stony Brook Univ.
10:30 Stem cells: story of Dr. Jekyll and Mr. Hyde.
S. P.S.
Monga. Univ. of Pittsburgh.
11:30 Smoking-related lung disease in 3D: not your standard
lecture.
D. S. Zander. Penn State Col. of Med.
12:15
Tour the exhibits at the Boston Convention & Exhibition
Center!
377. MOLECULAR AND CELLULAR BASIS OF
DISEASE: STOWELL SYMPOSIUM: CELL,
SCAFFOLD AND TISSUE ENGINEERING:
SUCCESSES ACHIEVED AND HURDLES YET TO
OVERCOME
Symposium
(Sponsored by: The Robert E. Stowell Endowment Fun)
t
ue
. 8:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 160B
C
haired
: B.e. p
etersen
anD
a. s
oto
-G
utierrez
8:30 Introduction.
8:45
Hepatic 3D culture system.
B. E. Petersen. Wake Forest
Univ. Baptist Med. Ctr.
9:30 TBD.
R. Schwartz. MIT.
10:15 TBD.
L. Griffith. MIT.
11:00
Hepatic research.
A. Soto-Gutierrez. Univ. of Pittsburgh.
11:45 Break.
2:00
Magnetic field and nano-antiobdy techncology toward
directed cellular differentation.
J. P. Dobson. Univ. of
Florida.
2:45
Liver graft macrosteatosis: quantitative morphological
assessment and methods to reduce lipid storage ex
vivo prior to transplantation.
F. Berthiaume. Rutgers
Univ., Piscataway.
3:30
Respiratory tract/organ engineering.
T. W. Gilbert.
4:15
Mesenchymal stem cell therapeutics.
B. Parekkadan.
TUESDAY NUTRITION/PATHOLOGY
104
378. SCVP SYMPOSIUM: INFLAMMATORY
MYOCARDIAL DISEASE/MYOCARDITIS
Symposium
(Sponsored by: ASIP and the Society for Cardiovascular
Pathology)
t
ue
. 8:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 160a
C
haired
: a. l
iChtman
C
oChaired
: l.m. B
uJa
Cardiac Pathobiology
8:30
How the heart protects itself against T cells.
A. Lichtman.
Brigham and Women’s Hosp.
9:15
Innate immune responses in the myocardium.
D. Mann.
Washington Univ.
10:00 Monocyte and macrophage subsets in myocardial
inflammatory responses to injury.
M. Nahrendorf.
Massachusetts Gen. Hosp.
10:45
Loss of tolerance in autoimmune myocarditis.
M. Lipes.
Harvard Univ.
379. ENDOTHELIAL CELL BIOLOGY AND
INFLAMMATION
Minisymposium
t
ue
. 8:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 161
C
haired
: s. C
olGan
8:30
379.1
Establishment and induction of arterial and
venous identities in human iPSC derived vascular endothelial
cells.
W.J. Adams, Y. Zhang and G. Garcia-Cardena. Brigham
and Women’s Hosp., Harvard Univ. and Harvard Med. Sch.
8:45
379.2
Molecular characteristics determining entry
into or exclusion from the endothelial cell lateral border recycling
compartment.
G. Feng and W.A. Muller. Northwestern Univ.,
Chicago.
9:00
379.3
Glycocalyx core proteins selectively mediate
endothelial NOS activation and cell alignment in response to
shear stress.
E.E. Ebong, D.C. Spray and J.M. Tarbell. Albert
Einstein Col. of Med. and City Col. of New York.
9:15
379.4
Endothelium exposed to atheroprone flow
promotes monocyte transmigration and specification.
A.
Turjman, E.R. Edelman and G. García-Cardeña. MIT,
Brigham and Women’s Hosp. and Harvard Med. Sch.
9:30
379.5
TNF-
a induced eNOS uncoupling mediates
endothelial dysfunction through elevated reactive oxygen
species.
E.J. Farrar, G. Huntley, K.S. Hsu and J.T. Butcher.
Cornell Univ. and Brown Univ.
9:45
379.6
Role of caveolae in the development of
abdominal aortic aneurysms.
K. Crawford, T. Takayanagi, S.
Eguchi and V. Rizzo. Temple Univ. Sch. of Med.
10:00
379.7
Nano-metal oxide aspiration exposure induces
endothelial dysfunction in mice.
M. Frame, A.M. Dewar and
S. Brenner. Stony Brook Univ. and Univ. of Albany Col. of
Nanoscale Sci. and Engin.
10:15
379.8
Kupffer cells potentiate the risk for liver
sinusoidal endothelial cell injury in sepsis through programmed
cell death receptor-1 ligation.
N.A. Hutchins , F. Wang, C-S.
Chung and A. Ayala. Brown Univ. Warren Alpert Sch. of Med.
and Rhode Island Hosp.
10:30
379.9
Dual activation of p38MAPK and SFK pathways
is required to induce endothelial permeability.
A.P. Adam, A.
Lowery and P. Vincent. Albany Med. Col.
10:45
379.10 Hypoxia-induced heparan sulfate primes the
extracellular matrix for cell recruitment by facilitating VEGF-
fibronectin interactions.
J.A. Buczek-Thomas, C.B. Rich and
M.A. Nugent. Boston Univ. Sch. of Med.
11:00
379.11 Maresin 1 a novel macrophage n-3 derived
mediator is a potent tissue regenerative immunoresolvent.
J.
Dalli, S. Karamnov, M. Zhu, N. Petasis and C.N. Serhan.
Brigham and Women’s Hosp. and Harvard Med. Sch. and Univ.
of Southern California.
11:15
379.12 A novel small molecule inhibitor to C-reactive
protein attenuates CRP’s pro-inflammatory effects in vivo.
I.
Jialal, P.R. Kumaresan, K.S. Lam and S. Devaraj. Univ. of
California Davis Med. Ctr., Univ. of Texas MD Anderson Cancer
Ctr. and Baylor Col. of Med.
380. NEURO-ONCOLOGY AND
NEURODEVELOPMENT
Minisymposium
t
ue
. 8:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 160C
C
haired
: W. t
ourtellotte
C
oChaired
: r. F
olKerth
Neuropathology
8:30
380.1
HDAC7 mediated activation of STAT3 in human
PTEN deficient glioma cells suppresses angiogenesis and
tumor growth in vivo.
A. Turtoi, A. Blomme and V. Castronovo.
Univ. of Liege, Belgium.
8:50
380.2
Neuregulin-1 overexpression and p53
haploinsufficiency cooperatively promote de novo MPNST
pathogenesis.
S.N. Brosius, A.N. Turk, S.J. Byer, N.M.
Brossier, L. Kohli, K.A. Roth and S.L. Carroll. Univ. of
Alabama at Birmingham.
9:10
380.3
BNIP3 regulates AT101-induced cytotoxicity in
MPNST cells.
N. Kaza, S.L. Carroll and K.A. Roth. Univ. of
Alabama at Birmingham.
9:30
380.4
Comparison of genomic profiling, cytogenetics,
and histology in adult and pediatric cases of medulloblastoma.
R. Schober, H. Holland, P. Ahnert, D. Fritzsch, L-X. Xu, W.
Krupp and J. Meixensberger. Univ. of Leipzig, Germany.
9:50
380.5
Role of Elp1 in neural crest cell migration,
differentiation and target tissue innervation in familial
dysautonomia.
M.Z. Jackson, K.A. Gruner and W.G.
Tourtellotte. Northwestern Univ., Chicago.
10:10
380.6
Striatal development involves a switch in
gene expression networks, followed by a myelination event:
implications for neuropsychiatric disease.
G. Novak, T. Fan,
B.F. O’Dowd and S.R. George. Univ. of Toronto and Ctr. for
Addiction and Ment. Hlth., Toronto.
10:30
380.7
Novel neuropathology in fetal alcohol
syndrome.
R. Folkerth, J. Smith, D. Zaharie and H. Odendaal.
Brigham and Women’s Hosp., Boston Children’s Hosp. and
Stellenbosch Univ., South Africa.
10:50
380.8
Egr3-dependent muscle stretch receptor
morphogenesis and innervation homeostasis.
M. Oliveira
Fernandes, K. Gruner and W.G. Tourtellotte. Northwestern
Univ. Feinberg Sch. of Med.
PATHOLOGY TUESDAY
105
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381. HCS SYMPOSIUM: PROTEOGLYCANS — KEY
REGULATORS OF THE IMMUNE RESPONSE TO
CANCER AND INFECTIOUS AGENTS
Symposium
(Sponsored by: The Histochemical Society)
t
ue
. 9:30
am
—B
oston
C
onvention
& e
xhiBition
C
enter
, 162a
C
haired
: n. s
aWtell
anD
C. W. F
revert
9:30 Syndecans, signaling and proteinases in breast
carcinoma.
J. R. Couchman. Univ. of Copenhagen.
10:10
Mass spectrometric profiling of glycosaminoglycans on
tissue histological sections.
J. Zaia. Boston Univ. Med.
Sch.
10:50 Glycosaminoglycans provide fine-tune control of
neutrophil migration and activation in lungs.
C. W.
Frevert. Univ. of Washington.
382. LUNCH & LEARN: COLLABORATING WITH
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