Organizing co mmittee

 
References: 
1.
P. Tiyas, P. Pooja, Sh. Abha. 
J. Mol. Struct
. -2021, Vol.1223, 128827 
2.
S.A. Amin, S. Banerjee, S. Singh, 
et al.
Mol Divers. - 
2021, Vol. 
25
, 1827
3.
G.M. Morris, R. Huey, W. Lindstrom, M.F. Sanner, R.K. Belew, D.S. Goodsell, 
A.J. Olson. 
J. Comput.Chem.
2009.-Vol.16, pp.2785-2791. 
N
N
O
AG
(AG - Aminoglycoside)
BE = -11.68 kcal/mol

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Poster presentation 
174 
EXTRACTION OF FLAVONOIDS FROM THE MEDICINAL 
PLANT Physalis alkekengi 
 
Z.A. Kadirova, Sh.S. Tаshmukhamedova, Sh.N. Mingnorov,
M.T. Saidova, D.K. Khojiyeva 
 
National University of Uzbekistan named after M. Ulugbek,
e-mail: [e-mail]  
Physalis alkekengi
from the Solanaceae family is characterized by a rich composition 
of biologically active substances (biologically active substances), that is, chemical 
substances with high physiological activity at low concentrations relative to the living 
organism. Among the biologically active substances synthesized and accumulated by 
the plant are alkaloids, steroids, flavonoids, carotenoids, polysaccharides, lectins, 
pectins, vitamins, fatty oils, tannins (tannins), etc. The purpose of the research is 
Physalis alkekengi
is to choose the optimal conditions for extracting flavonoids from 
the plant and to determine the flavonoid content in the dry extract.
Research materials and methods: in the study, ethanol was used in concentrations 
from 40 to 90% to separate flavonoids. The obtained mass was dried in a lyophilic dryer 
using liquid nitrogen. The content of flavonoids in the obtained dry extracts was 
determined in relation to luteolin. Quantification of flavonoids was carried out in a 
spectrophotometer.
Discussion results: the effect of some factors on the release of flavonoids, namely the 
concentration of the extractant, the particle size of the raw material, the effect of the 
incubation time and the ratio of the raw material to the extractant in the study on the 
selection of optimal conditions for the extraction of flavonoids from 
Physalis alkekengi
was studied. The effect of extractant (ethanol) concentration was studied to determine 
the completeness of flavonoid extraction from the plant, and at low concentrations 
(20%, 30% and 40%) flavonoid release ranged from 0.25 to 0.55 mg It was found that 
flavonoids were completely extracted by ethanol at a concentration of 80%. In this case, 
the flavonoid concentration was 1.92 mg. A further increase in the concentration of the 
extract did not lead to an increase in the extraction efficiency of flavonoids. The 
extraction time of flavonoids from 30 to 135 minutes of incubation time flavonoidl 
within 105 minutes while studying the effect on efficiency It was determined that ar can 
be completely obtained from plant materials. When choosing the degree of grinding, the 
diameter of plant holes is 0.5; 1.0; 2.0; 3.0; They used 4.0 and 5.0 mm raw material 
particles. From the obtained data, it is known that the maximum extraction of flavonoids 
from the plant is achieved by grinding the raw material to a particle size of 2.0 mm. is 
carried out (the number of flavonoids is 1.93 mg).
Conclusion: A method of extracting dry extract and flavonoid content from the plant 
Physalis alkekengi
was developed. The methods of obtaining biologically active 
substances of the medicinal plant 
Physalis alkekengi
were analyzed. The optimal 
conditions for obtaining flavonoids of the studied object were selected. 80% ethyl 
alcohol with 0 mm raw material particles was optimal for the extraction of flavonoids, 
and the raw material: extractant ratio was 1:100, and the extraction time was 105 
minutes. 

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Poster presentation 
175