Organizing co mmittee

1 2 
Fig. 1. Chemical structures of isolated compounds 
1–5
: 1-
O
-methylemodin (
1
), 
stigmasterol (
2
). 
 
 

---

Poster presentation 
161 
GERFINE - NEW ALKALOID FROM Haplophyllum griffithianum 
 
D.R.Kodirova, Kh.A.Rasulova 
 
S.Yu. Yunusov Institute of the Chemistry of Plant Substances Academy of sciences 
of the Republic of Uzbekistan st. Mirzo-Ulugbek, 77, 100170 Tashkent
e-mail: [e-mail] 
 
The pharmacological studies of alkaloids and their derivatives isolated from plants of 
Haplophyllum
genus 
(fam. Rutaceae
), which are unique source of various alkaloids, 
showed that they are low toxic and have wide spectrum of pharmacological action. 
Most of them possess by inhibitory action on CNS, sedative, sleeping, anticonvulsant, 
estrogen and other effects. 
As a result of research of total alkaloids with yields 0,4% and 0,58% respectively, 
which isolated from the aerial part and roots of 
H. griffithianum
collected in 
Sanchardaksoy, Nilu village, (Surkhandarya province). The known alkaloids 
skimmianine, dictamnine, dubinine, dubamine, a gerfitin with m.p. 91-93

C, gerfitinin 
with m.p. 91-93

C and a new bases – gerfin were isolated for the first time from the 
aerial part, and skimmianine, dictamnine, dubinine and sterols with m.p. 76-78

C, and 
60

C – from the roots. The structure of gerfine (I) was proved by spectral data.
Gerfine (
1
): ESI-MS 
m/z
227 (M
+
), C
14
H
13
NO
2, 
(CHCl
3
:MEOH, 9:1) (R
f
0.70).
1