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advanced-chemistryprize2021
P* (step 6). P* is a powerful oxidant that can remove an electron from a sacrificial enamine to
generate P
–
(not shown in Scheme 6). P
–
, in turn, is a reductant that reduces the alkyl halide
to the corresponding alkyl radical and bromide ion, as well as regenerating photoredox
catalyst P (step 2). The alkyl radical then enters the organocatalytic cycle and combines with
enamine 37 to furnish a new open-shell species, radical 38 (step 3); note that in this step a
new carbon-carbon bond is formed as well as a new stereocentre. Intermediate 38 is oxidized
by the excited photoredox catalyst P*, affording enamine 39 and P
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