Tezislər / Theses

 
 
 
 

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THE 3
rd
 INTERNATIONAL SCIENTIFIC CONFERENCES OF STUDENTS AND YOUNG RESEARCHERS 
dedicated to the 99
th
anniversary of the National Leader of Azerbaijan Heydar Aliyev
393
SYNTHESIS OF NEW PYRIMIDINE DERIVATIVES 
Sona Babayeva 
Baku State University 
Baku, Azerbaijan 
[e-mail] 
Supervisor: Professor Ibrahim Mamedov 
Keywords:
pyrimidine, heterocycle, NMR 
Pyrimidines are N-containing six-membered heterocyclic compounds with 
a wide range of biological and medicinal activity including antitumor, analgesic, 
antibacterial, antifungal, etc. In addition, pyrimidines with the extended 
conjugation pi system are potential scaffolds for light-emitting devices and 
molecular wires, also find their application in supramolecular chemistry [1-3]. 
Due to the applicability in the medicinal industry, supramolecular, and 
coordination chemistry, different synthesis methods of pyrimidines have 
been studied in the literature. [2,3]. 
The reported work is devoted to the synthesis of pyrimidine derivatives 
given below. The synthesis was carried out based on relevant chalcone 
derivatives in the presence of the oxygenating agent.
The structures of (
E
)-2-(2-amino-6-styrylpyrimidin-4-yl) phenol
(1), (
E
)-2-(2-amino-6-styrylpyrimidin-4-yl)-4-methylphenol
(2) and 2-(6-(2-(allyloxy)-5-bromophenyl)-2-aminopyrimidin-4-yl)-4-methylphenol
(3) were confirmed by NMR spectroscopy. 
References
[1] Khandelwal, S., Tailor, Y. K., Rushell, E., & Kumar, M. (2020). Use of sustainable 
organic transformations in the construction of heterocyclic scaffolds. Green Approaches in 
Medicinal Chemistry for Sustainable Drug Design, 245–352. 
[2] Sharma, R., & Kumar, A. (2020). Sonochemical protocol for Catalyst-Free Organic 
Synthesis. Green Sustainable Process for Chemical and Environmental Engineering and 
Science, 43–70. 
[3] M.V.Jyothi, Y.R. Prasad, P. Venkatesh, M.Sureshreddy, 2012, Chemical science 
transactions
 
, p. 716.