Yazışma Adresi /Correspondence: Merve Yazıcı Kara

ÖZGÜN ARAŞTIRMA / ORIGINAL ARTICLE

Yoğun bakım ünitesinde HELLP Sendromu ve eklampsi hastalarına uygulanan 

plazmaferez tedavisinin etkinliği

The effectiveness of plasmapheresis treatment in the patients with HELLP Syndrome and 

eclampsia in the intensive care unit

Merve Yazıcı Kara

1

, Sanem Çakar Turhan

2

, Ali Abbas Yılmaz

3

, Mehmet Oral

4

ABSTRACT

Objective: In our study we aimed to state the effective-

ness of plasmapheresis treatment in the patients with 

HELLP Syndrome and eclampsia in the intensive care 

unit.

Methods: Patients who are with the diagnosis of HELLP 

Syndrome and eclampsia in our intensive care unit be-

tween the years of 2005-2010 were reviewed retrospec-

tively. The patients’ characteristics, before and post-

plasmapheresis biochemical and hematological values, 

urine outputs, APACHE II (Acute Physiology and Chronic 

Health Evaluation System), GCS, (Glasgow Coma Scor-

ing), SOFA (Sequential Organ Failure Assessment) and 

MODS Scoring (Multiple Organ Dysfunction Score) are 

recorded. The effectiveness of plasmapheresis is evalu-

ated.

Results: 8 were HELLP Syndrome and 6 were eclamp-

sia of 16 patients. The mean age was 29,5(±5,9). 2 of 6 

eclampsia patients and, 1of 8 HELLP Syndrome patient 

were died. Age, APACHE II, MODS, GCS and the urine 

output are the significant clinical factors that determines 

the mortality (p<0.03). After the plasmapheresis therapy 

a significant improvement was seen in platelet and total 

protein numbers, MODS score, AST, GGT, LDH, lactate 

and creatinine levels. (p<0.03) 

Conclusion: Plasmapheresis treatment in the patients 

with HELLP Syndrome and eclampsia is a safe method 

and  provides  a  significant  development  in  biochemical 

values and patients’ clinics.

Key words: HELLP Syndrome, Eclampsia, Plasmapher-

esis