Year: 2003 Author: Deniskina, Elena V. Thesis

Year: 

2003

Author: 

Deniskina, Elena V.

Thesis: 

Clinical and laboratory study hirudotherapy in treatment of chronic apical periodontitis

Academic degree of: 

PhD

Place of defense of the thesis: 

Moscow

Discipline Code WAC: 

14.00.21

Specialty: 

Stomatology

Number of Pages: 

160

Note The following scientific texts are available for inspection and received recognition through the original texts of dissertations (OCR). In this connection, they may contain errors due to imperfect recognition algorithms. The PDF files of abstracts of theses and delivered from such errors, RSL no.

Contents: 

INTRODUCTION. 

1. Review of the literature. 
1.1. Mechanisms of anti-inflammatory effect of occupational therapy. 
1.2. The effectiveness of occupational therapy in inflammatory diseases of the maxillofacial region. 
1.3. Modern methods of treatment of chronic apical periodontitis. 
1.4. Application of occupational therapy in the treatment of chronic apical periodontitis.

Introduction: 

Background

Diseases of the apical periodontal inflammatory nature of the frequency of referral of patients in third place after caries and pulpitis, and are in the structure of the dental pathology of 30-50% (Borovsky EV, 1999). Exacerbation of chronic apical periodontitis is often accompanied by a violation of general condition, pain, erythema and edema of the mucous membrane of the alveolar process, collateral edema in soft tissues (Posmetnaya T. et al., 1995). Chronic forms of periodontal disease without exacerbation sometimes occur without marked clinical manifestations, however, for an organism are a source of chronic infection. In the pathogenesis of apical periodontitis plays an important role not only local non-specific resistance of the organism, but the state of immunity in general (Khaitov PM, 1995; Volozhin AI, 1999; Karaulov AV, 1999, VN Alexandrov et al. , 2000).

For the treatment of chronic apical periodontitis in modern dentistry, various methods and drugs, which choice is largely determined by how the etiology and clinical disease (VV Zorin, 1990; Ivanov BC, 1990, Zuev VP, et al. , 1996; Barer GM, Volozhin, SA, 1997, Barer GM, et al. 1997; Maksimovskiy JM, et al. 1997; TV Alekseeva, 1998; Ovchinnikov I. A. 1998; Lukicheva LS, 1998, Kuryakin, VV, 1998; Poletayev, EA, 2000 A. Zakarian, 2002). Methods and medicines are not always effective. Despite the quality of endodontic treatment is often not fully restore bone in the zone of destruction (Botbaev BD, 1990; Burduli MP, 1990, EA Volkov, 1990; Volkov, EA et al., 1997 ; Maksimovskiy YM, 1996). The use of antibiotics, immunomodulators, steroids and nonsteroidal anti-inflammatory drugs, physical therapy techniques for the treatment of chronic apical periodontitis is limited by the individual intolerances, allergies and related (OP Maksimova, 2002; Zorian EV, 2002; Winkel EG et al ., 1998). In this regard, increasing attention to attract dentists traditional methods of treatment and, in particular, occupational therapy, as it has a systemic and multidimensional effect on the course of the inflammatory process, which is due to the presence of biologically active substances in the salivary gland secretions of the medicinal leech (GI Nikonov , 1998; Savinov VA, 1998; Hamsters JN, 2000; Yang Tong, Ma Zhong-cai, 1995; Baskova I. et al., 1999; Zavalova L. et al, 1999).

In the available literature, there are only a few works that evaluated the clinical efficacy of occupational therapy in exacerbations of chronic apical periodontitis (Zidra SI, et al., 1996, 1997, 1998).These works were carried out on small materials, evaluation of treatment outcomes was conducted only on clinical parameters. The question of the pathogenetic validity of occupational therapy in the treatment of chronic apical periodontitis remained unresolved until the end.

The aim of the study. Evaluate the effectiveness of occupational therapy in the treatment of chronic apical periodontitis during exacerbation and aggravation out on the basis of follow-up using clinical, laboratory and functional methods.

Objectives of the study.

1. Develop a methodology for occupational therapy in treatment of chronic apical periodontitis.

2. To assess the dynamics of clinical manifestations (in points) of chronic apical periodontitis under the influence of occupational therapy.

3. To study the dynamics of the X-ray, radiovisiography, densitometry in chronic apical periodontitis under the influence of occupational therapy.

4. On the basis of determining the level of middle molecules in the mixed saliva of patients with chronic apical periodontitis study detoxication effect occupational therapy.

5. Rate this anti-inflammatory effect occupational therapy in patients with chronic apical periodontitis according to the cytology of mixed saliva.

6. To study the dynamics of the content of lysosomal-cationic proteins in neutrophils mixed saliva of patients with chronic apical periodontitis under the influence of occupational therapy.

Scientific novelty of the work. For the first time carried out clinical and laboratory evaluation of the effectiveness of occupational therapy in the treatment of chronic apical periodontitis in the acute stage and without exacerbation. Found that use of combined treatment of occupational therapy in exacerbations of chronic apical periodontitis allows the earliest possible time to arrest the pain, swelling, inflammation syndrome. Application of occupational therapy in chronic apical periodontitis prevents the development of clinical manifestations of exacerbation after endodontic treatment.

For the first time on the basis of research performance level of middle molecules mixed saliva found that occupational therapy in patients with acute exacerbation of chronic and out of apical periodontitis has a strong detoxification effect.

According to the cytology unstimulated mixed saliva objectified anti-inflammatory effect occupational therapy. In the mixed saliva of patients with acute exacerbation of chronic apical periodontitis in the process of occupational therapy reduced rates cytosis and absolute content of neutrophils.

For the first time found that occupational therapy during exacerbation of chronic apical periodontitis activates nonspecific mechanisms of local immune defense, increasing the content of lysosomal-cationic proteins in neutrophils mixed saliva.

The practical significance. It is developed, justified, implemented, and recommended a practical method for dental occupational therapy in complex treatment of patients with acute exacerbation of chronic apical periodontitis and without exacerbation.

According to clinical and laboratory studies found that occupational therapy during exacerbation of chronic apical periodontitis, relieves swollen, painful, inflammatory syndrome and reduces the treatment time.

Application of occupational therapy in chronic apical periodontitis prevents development of disease exacerbation after endodontic treatment.

Hirudotherapy, compared with pharmacotherapy and physical therapy, has a limited number of side effects and contraindications.

Provisions are brought to protect

1.Primenenie occupational therapy in the treatment of patients with chronic apical periodontitis has a pronounced clinical effect, relieves pain, swelling and inflammatory syndrome.

2. Under the influence of occupational therapy in patients with chronic apical periodontitis decreases the level of middle molecules in the mixed saliva, indicating a pronounced detoxification effect of secretion of the medicinal leech.

3.Girudoterapiya has anti-inflammatory effect on these cytology of mixed saliva. In the process of occupational therapy

A '^ CI' u reduced rates cytosis and neutrophilia mixed saliva.

4.Girudoterapiya activates nonspecific immune mechanisms of local protection of the oral cavity in patients with acute exacerbation HVP, increases lysosomal-cationic proteins in neutrophils mixed saliva.

Publication. On the topic of the thesis published 12 printed works:

Testing and implementation of the results. The main provisions of the reported and discussed at a scientific conference of young scientists MGMSU (Moscow, 2001), at a scientific conference Institute of Human Morphology, RAMS, "Current issues of morphogenesis in health and disease" (Moscow, 2002), the All-Russian Conference "compensatory-adaptive processes "(Novosibirsk, 2002).

Testing the thesis held by the joint meeting of chairs propaedeutics of dental diseases, Faculty Dentistry, Faculty of Dental Surgery course of implantology, surgical departments and CDC MGMSU TsNIIS and laboratory immunomorphology Institute of Human Morphology, Academy of Medical Sciences (December 2002, Moscow).

The method used in the clinic hirudotherapy Department propaedeutics MGMSU dental diseases, based on a central clinic IPU number 2 in Moscow. Results of the study are used in the classroom with residents, graduate students, for faculty training of doctors and teachers MGMSU.

1. Literature Review

Conclusion: 

Findings

1. According klnnnko-laboratory evaluation of the current exacerbation of chronic apical periodontitis found that the use of combined treatment of occupational therapy allows an earlier date to arrest the pain, swelling, inflammatory syndrome and reduce treatment time.

2. In the application of medicinal leeches in patients with acute exacerbation of chronic apical periodontitis severity of spontaneous pain and pain on percussion, collateral edema, hyperemia and edema of the mucous membrane of the alveolar process of the causative tooth was reduced by 3 to 5 days and disappear on the 7-10th, whereas in patients without the use of occupational therapy, the symptoms persisted for 7 to 10 days.

3. Based on clinical data and results radiovisiography, bone densitometry in patients with chronic apical periodontitis in the application of occupational therapy revealed a marked tendency to improve the periapical tissues relative to the comparison group.

4. Hirudotherapy in patients with chronic apical periodontitis has a strong detoxification effect, with significantly reduced levels of middle molecules in the mixed saliva. While in the comparison group level of middle molecules significantly increases.

5. Anti-inflammatory effect in occupational therapy, exacerbation of chronic apical periodontitis was confirmed by cytology of mixed saliva. In patients with statistically significant reductions in cytosis and the absolute content of neutrophils in mixed saliva. b. Hirudotherapy in patients with exacerbation of chronic apical periodontitis increases the content of lysosomal-cationic proteins in neutrophils mixed saliva, which reflects the normalization of the status of their systems kislorodonezavisimoy and activation mechanisms of the local non-specific immune defense.

Practical advice

1. Application hirudotherapy in the complex treatment of patients with chronic apical periodontitis has a pronounced anti-inflammatory, analgesic and dekongestivny, detoxification effects. The technique hirudotherapy, which is directed by 2.1 of medicinal leeches in the mucous membrane of the alveolar bone in the apex of the projection "causal" tooth. The treatment course is 1-3 sessions, with intervals of 2-3 days using the aspiration method.

2. Hirudotherapy allows the earliest possible time to arrest the inflammatory syndrome and reduce treatment time.

3. Use appropriate hirudotherapy to prevent activation of the inflammatory process in patients with chronic apical periodontitis after endodontic surgery.

4. Hirudotherapy helps restore bone in the periapical foci of destruction according to local densitometry with the assessment of periapical index.

5. Hirudotherapy patients with chronic apical periodontitis normalizes kislorodnezavisimoy system-lysosomal cationic proteins in neutrophils and activates nonspecific mechanisms of local immune defense.

References 

1. Alekseeva T. Comparative analysis of different forms of treatment of pulpitis and periodontitis with the use of zinc-evgenolovoy paste, gutta-percha and korpasty / / Actual problems of medicine: Proc. Conf.MMSI. M., 1998. - P.49 

2. Alexandrov, VN, Kuraskua AA, Pozniak-Chuchman VV, Shanin VY Immunological component in the pathogenesis of granulomatous periodontitis / / Institute of Dentistry. 2000 .- № 2 (7),. 18 
3. Andreev BV, Ignatov YD Effect of blockers on the analgesic effect of GABA positive drug / / Bull. exp.Biol. Medicine, 1986. -99 .- With. 438-439 
4. Asiyatilov AH Some features of the clinical manifestations of complicated forms of chronic periodontitis / / Proceedings of III Congress of the RSFSR dentists, Volgograd. 1976 .- with. 284-287 
5. Afanasiev, GA, Chesnokov, NP, Kirichuk VF Changes in the level of middle molecules in the blood of rats under the influence of electromagnetic radiation of millimeter range / / Homeostasis and infectious process, with 2002 .-. 9 
6. Bazhanov NN, Dmitrieva, BC, PE Arzhantsev and other acute purulent diseases of soft tissues of the maxillofacial area / / All-Union Congress of dentists: Proc. Conf. Tashkent.-1981.-c. 11-15. 
7. Bazhanov NN, Casini V. Experience in clinical use hirudotherapy maxillofacial surgery / / Asklepeyon, Annex 2, Bryansk. October. 2001 .- with. 8 
8. Bazhanov NN, Yusunhodzhaev 3. Smirnova, GD, PB Verkhovskaya The dynamics of blood biochemical parameters in patients with purulent-inflammatory diseases of soft tissues of the face and neck / / Dentistry. -1990. , P.26-29. 
9. Balayan JI.B. Treatment of chronic periodontitis using brefoosteoplasta (Clinico-experimental study): Aftoref. Dis. cand. med. Science .- M., 1986 .- 23 p.. 
10. Balashov, AN Modern methods of endodontics. M. - 1984. 
11. Barer GM, Ovchinnikov IA Zavialov, VA, Oil VG Ultrasound through the prism of Endodontics / / C.Dentistry, 2002 .- № 1, p. 32-34 
12. Barer GM, Volozhin SA Application gidrooksiapolsoderzhaschey zinc evgenolovoy paste to seal the canals in treating periodontitis / / Dentistry. 1996. № 5. - P.26-27. 
13. Barer GM, Volozhin SA Gidroksiapol means improving the properties of zinc-root paste evgenolovoy / / Proc. Conf. IV Ros. Nat. Congress "Man and medicine." - M. ​​- 1997. - With. 14. 
14. Barer GM, Kocherzhinsky VV, Ovchinnikov IA Effect of topical application of antibacterial drugs for a chronic periodontitis / / clinical. dentistry. -1997 .- № 3.-p.12-14. 
15. Banchenko GV The combination of diseases of the oral mucosa and internal organs / / M - 1979 
16. Batiuk, NM Experience of treatment of apical periodontitis / / Ways of dentistry: Results and Prospects: Proc Conf. dentists. Ekaterinburg .- 1995. - P.69-72. 
17. Batiuk, NM Slobodenyuk VK Treatment of chronic periodontitis using the drug erakond / / Problems of organization and economics of dentistry. Ekaterinburg .- 1994. , P.61-62. 
18. Batiuk, NM Rehabilitation of patients with apical periodontitis / / Abstract. diss. MD Ekaterinburg, .- 1996. -18 S. 
19. Bezrukov VM, Grigorian AS Giroksiapatit as a substrate for bone grafting: theoretical and practical aspects of the problem / / Dentistry. -1996. № 5. - P.7-12. 
20. Rich AI A method for treating chronic periodontitis multirooted teeth of the mandible / / New progressive in public health practice. Ulyanovsk, 1994. - P.72-73. 
21. BN Borisov Medical treatment of root canals in the treatment of periodontitis ortofenom / / Dentistry.1990. -T.69, № 6. , P.79. 
22. Borowski E. Treatment of periodontitis status of the problem and prospects for improving / / Dentistry. Spec. issue. -1996.-P.38-39. 
23. Borowski E. Endodontic problems / / Clinical Dentistry. 1997. - № 1. - P.5-8. 
24. Borovsky EV, Zhohova NS Endodontic treatment (manual for physicians). M., 1997. - 64. 
25. Borovsky EV, Svistunov IA Kochergin VN Yes or No resorcinol-formalin method (Albrecht) / / Clinical Dentistry. 1997. - № 3. - S. 16-18. 
26. Borowski E. Clinical Endodontics / / M., 1999 .- 176 sec. 
27. Botbaev BD Surgical treatment of cysts of jaws with biogenic plastic materials based on hydroxyapatite and brefokosti: Author. Dis. . PhD. med. nauk.-M., 1990.-24c. 
28. Budaevskaya TV Indicators of sensitivity of microorganisms to anitseptikam with apical periodontitis / / Dentistry. -1989. № 3. - P.23-25. 
29. Budaevskaya TV Justification of the choice and ratsionalnogoprimeneniya antiseptics for the treatment of apical periodontitis: Abstract. Dis. cand. med. Science. -M .- 1993. 17 sec. 
30. Budaevskaya TV Adarchenko AA, Sosnin GP Indicators of sensitivity of microorganisms to antiseptics in apical periodontitis / / Dentistry. 1989. - № 3. - S. 23-25. 
31. Burduli MP The role of the stimulation of reparative osteogenesis in the treatment of chronic periodontitis: Abstract. Dis. . cand. med. Science. Tbilisi .- 1990. - 24 sec. 
. 32 Burov, BM Treatment of patients with chronic apical periodontitis in a shorter period / / Diss. . cand.med. Science. 1981.-Poltava.-C. 18. 
. 33 Vinichenko YA, AV Vinichenko Mathematical prediction of some aspects of root canal instrumentation / / Act. Questions endodontics. M. - 1990. - P.7-11. 
34. Vinokourov VD Hirudotherapy in the treatment of patients stomatonevrologichekih / / Collection of scientific articles based on conference nuchnyh girudologov Association, 1992-1997, Vol. 1, Moscow - 1998.-p.41 
35. E '. Jb EA Treatment of chronic apical periodontitis with the use of drugs and stimulants immibilizirovannyh osteogenesis / / interterritorial scientific. prakt.konf. spa dentistry: mes. Conf. - Kislovodsk .- 1990. -P.26-27. 
36. Volkov EA, Grechishnikov VI Experimental study of the use of "Polisorya" in the treatment of chronic destructive periodontitis / / silica in medicine and dentistry. , Kiev, Stavropol .- 1993. P.251-253. 
37. Volkov EA, Lysov AV Garus YN, MM Lysova Results of treatment of chronic apical periodontitis using gidrokilapatitnoy ceramics / / Actual problems of clinical dentistry. Stavropol .- 1997. - P.43-45. 
38. Volozhin AI Features of the pathogenesis of chronic periodontitis / / Act. Vopr. Endodontics. M. 1990.- S. 11-14. 
39. Volozhin AI Inflammation (etiology, pathogenesis, treatment guidelines). Moscow: MMSI, 1996. -111s. 
40. Volozhin AI, Barer GM Grigorian AS, Volozhin SA The root paste on the basis of gidroksiapola firm "Polysteel" / / News of dentistry. - 1996. № 5. - SZ 
41. Volozhin SA Treatment of apical periodontitis with toothpaste on gidokisiapola (clinical and experimental research): Abstract. Dis. cand. med. nauk.-M. - 1997.-17c. 
42. Volchenkova GV Use of occlusive «Thermafil» in the treatment of patients with chronic periodontitis large and small molars / / Act. challenges of dentistry. Smolensk-.- 1997. -P.44-47. 
43. Volchenkova GV Kupreeva IV Conservative treatment of chronic apical periodontitis large and small molars / / Modern technologies in dentistry. Smolensk .- 1998. S. 46-48. 
44. Volfenzen II The use of biologically active substances in kosmetitke / / TSNIITEI food industry. 1973. 
45. Vorobiev BC, Vinichenko Y. Instrumental and pharmacological treatment of root canals / / Act. Vopr.Endodontics. -M .- 1990. P.14-18. 
46. Vorobiev Y., Volozhin AI, Bogushevskaya VB, Drone II Clinical and radiographic evaluation of hydroxyapatite with collagen in treating periodontitis and radicular cysts / / Dentistry. - 1995. - T.74, № 2 - P.34. 
47. Gabriele NI, Dmitriev AA, Kulakov GP Diagnostic value of determining middle molecules in blood plasma in nephrological diseases / / C. Medicine 1981, № 10 .- with. 38-42 
48. Garus YN Volkov, EA, AV Lysov Clinical efficacy of drug use of hydroxyapatite in the treatment of chronic destructive periodontal apical / / IV final scientific. Conf. young scientists and students. Stavropol .- 1996. P.88-89. 
49. Gerasimchuk AA The use of composites based on hydroxyapatite in the treatment of chronic periodontitis / / Path sovershenistvovaniya dental care in Kazakhstan. Alma-Ata .- 1989. P.47-49. 
50. Gileva OS, Experimental and clinical substantiation of the functional, performance evaluation of hirudotherapy in the treatment of diseases of the oral mucosa / / Abstract. diss. MD, MA, 1997 .- 36. 
51. Gileva O.S, Antipin NA, Sour, F., T. Kardinova, Anosov IA Hirudotherapy from a position of dental / / problems biotherapy collection of abstracts and papers, Moscow, 1998 .- p.. 16-17 
52. Glinkina V. Don GI Results of treatment of chronic periodontitis exacerbated with the use of sorbents / / Dentistry. -1991. № 4. - P.35-36. 
53. Goncharov, I., Bazikyan EA Increasing hydroxyapatite osseointegration in the surgical treatment of chronic periodontitis juxtahilar cysts / / Dentistry. 1996. - Spec. Vol. -P.50-51. 
54. Goncharova EI, Biserova NG, Karaulov BA Comparative data of root canal with periodontitis / / Act.Vopr. Endodontics. Moscow, 1990. - P.28-30.ya * & -*, 55. Gorovoy B. Ya, Ivanov BC Filling materials based on epoxy resins. M.: Medicine, 1973 .- 175 sec. 
56. Grigorian AS, Volozhin, SA, Antipov ZP and other Experimental testing of the root paste on the basis of hydroxyapatite / / Dentistry. 1996. - T.75, № 1. - P.7-11. 
57. Grigorian AS, Panikarovsky VV, TK Khamrayev etc. A comparative study of two routes of administration hydroxyapatite granules / / New in technical development of dentistry: Proceedings of the conference. Dental. Ekaterinburg, 1992.-p.118-121. 
58. Grigoriants JI.A., Zuev, DV, Badalyan, VA et al Surgical treatment of jaw cysts juxtahilar using hydroxyapatite ultra-high dispersion without resection of the tips of the roots / / Clinical Dentistry. -1997. № 3. , P.54-58. 
59. Grigoriants JI.A., Zuev, DV, Belova, E., Kopecky IS Surgical treatment of jaw cysts juxtahilar using hydroxyapatite ultrasonic disperstnosti without resection of the tips of the roots / / Clinical Dentistry.1997. - № 3.-p.54. 
60. Grigoriants JI.A., Podoinikova MN The clinic, diagnosis and treatment of perforated teeth / / Clinical Dentistry. 1998. - № 4.-p.58. 
61. Gunchenko JI.C., Bogatyrev VA Ways to improve the effectiveness of treatment of pulpitis and periodontitis / / Act. Vopr. Endodontics. M., 1990 .- p.34-37. 
62. Grandfather JI.H., Denisov JI.A. Treatment of apical periodontitis with the use of the combined effect of focal dosage vacuum and local darsonvalization / / Dentistry. 1991. - № 1. - P.26. 
63. Demedenko AT, Minakov AP Sukachev AN Chilikin LV Hirudotherapy in the complex treatment of periodontal disease / / Asklepeyon, № 1,1994 .- with. 31-32nfV-t J { 
64. Demin TA, Gileva OC Experience hirudotherapy BS "complex treatment of patients with chronic воспалительнымизаболеваниями oral mucosa and periodontal / / Proceedings of the conference acc-tion girudologov, St. Petersburg, Zelenogorsk, 1997 .- with. 31 
65. Denisov AB Salivary glands. Saliva / / M., 2000 .- 246 sec. 
66. Denisov IA, Jafarov AD, Ulyanov TV etc. The use of lysozyme-elektoroforeza for the treatment of chronic periodontitis / / Dentistry. 1987. - № 3. - P.28-30. 
67. Dzeh SA Clinical and immunologic disorders, hirudotherapy syndrome patients Rossollimo-Melkerssona-Rosenthal / / Abstract. diss. MD M. - 2000 
68. Dobrohodova ID Our experience with the system «Thermafil" in the treatment of complicated forms of dental / / Nauch .- Scient. Magazine "The Institute of Dentistry." 1998. - P.42-43. 
69. Dolgushin II, Bukharin OV Neutrophils and homeostasis / / Yekaterinburg, 2001 .- 277 sec. 
70. Drozdova RK, Rehachev VM, Vinogradov IE et al Evaluation of microflora of root canals with apical periodontitis in St. Petersburg residents in different years / / Dentistry . 1996., Spec. Vol. - p.53-54. 
71. Elnikov AY chronic periodontitis cause inflammation of the sinus / / dentistry, Kiev, "Health", 1977 .- p.. 30-31 
72. Zhohova N. Comparative evaluation of canal filling using different types of pins: Author. dis. Cand. med. science.-M., 1997.-24. 
73. Zhohova NS, Makeyev IM endodopticheskih Classification Tool and some aspects of its application / / new in dentistry. 1996. № 5. - P.7-10. 
74. Zhohova NS, Makeyev IM tooling as the key to successful obturation of root canals with gutta-percha / / New in dentistry. 1997. - № 4. - P.22-27. 
75. Zhohova NS, Makeyev IM Appliances obturating root canals using lateral condensation method and system Thermafil / / new in dentistry. -1997. № 5. - S. 10-12. 
76. Zakarian A. Electrophoresis of copper-calcium hydroxide in the treatment of chronic apical periodontitis in teeth with hard to reach root canals / / Abstract of Thesis.. PhD M. 2002 .- 18 sec. 
77. Zaripov S. S. Treatment of acute exacerbations of chronic apical periodontitis applications prednizalon / / VI National Conference of dentists: Dental caries and its complications. Izhevsk, 1988. - P.57-58. 
78. Zidra SI Sukachev AN, AT Demidenko, Minakov AP Faraschuk FF Hirudotherapy in the complex treatment of complicated forms of dental / / Proceedings of the IV Conference of the Association girudologov. Moscow, 1995 .- p.. 16 
79. Zidra SI Methods traditional medicine and new drugs in dental practice / / Volgograd 1994.-s. 93-95 
80. Zimin) D Goryunov AI Zyablikov VV, Safayev NM Effect of medical leeches on the acid-base status okoloranevoy capillary blood after treatment and drainage of purulent wounds / / Uspekhi girudologii. Proceedings of the III Conference, Moscow, 1993 .- p.. 26 
81. Zoloeva Z.E., Drone, VP, Olevskaya E.G . Application of directed tissue regeneration in combination with hydroxyapatite "Ostim 100" for the treatment of functional defects / / Periodontics. -1998. № 3 (9). - p. 31. 
82. Zorin VV Complex method of treatment apical periodontitis / / interterritorial Scientific-Practical. Conf. spa dentists: Proc. Conf. Kislovodsk, 1990. - P.35-36. 
83. Zuev VP, Dmitrieva JI.A., Filatova NA, etc. The use of Ostim -100 in the complex treatment of periodontal diseases / / new in dentistry. 1996. - № 2.-C. 15-18. 
84. Zuev, VP Sergeev, PV, AS Pankratov et al Dynamic study intensity of the culture of osteoblast mitogenesis in the presence of hydroxyapatite ultra-high dispersion / / Dentistry. 1994. - № 2. - p.5-7. 
85. Ivanov AS, Balamtsov A. Long-term results of treatment of apical periodontitis / / Act. Vopr. endodontics. M. 1990. C-40-42. 
86. Ivanov AS, AK Iordanishvili Infectious apical periodontitis: Lectures on dentistry. SPb, 1992.-57C. 
87. Ivanov BC, Ovrutsky G.D . Haemon V. Practical endodontics. Moscow: Meditsina, 1984. - 23 s.l; * f 
88. Ivanova EV-Ekspernmentalno klinichskoe rationale of a new composition for the treatment of pulpitis and periodontitis / / Abstract. dis.. PhD . med. sciences. M. - 1994. 
89. Ivanova EV, Morozova JI.B. Results of microbiological study of a new composition for filling root canals / / Act. Vopr. endodontics. Moscow, 1990. - p.43 -46. 
90. Karaulov AV Clinical Immunology / / M-1999 
91. Katurova GF, Salimova EP, Tochilovskaya RV, etc. The use of celandine and DMSO in the treatment of periodontitis / / Act . Vopr. endodontics. Moscow, 1990. - P.47-49. 
92. Kirilova VP treatment of chronic periodontitis with the use of low-frequency ultrasound and iodpirona. Abstract. dis.. Cand. med. science.-M .- 1986 . 
93. Kodukova A. Velichkova P., B. Dachev periodontitis. Moscow: Meditsina, 1989. - 256. 
94. Kozonova I. T. The use of proteolytic enzymes in the treatment of acute and chronic forms of periodontitis / / Sat mes. XX final Intercollege. scientific. Conf. Young Scientists. Moscow, 1989. - p.41-42.
95. Kononovich EF, Volosevich LI, Krivohatskaya LD, Sheremet ZA Rationale antibacterial agents for the treatment of periodontitis / / Dentistry. 1989. - № 3. - P.21-23. 
96. Krashenyuk AI Krashenyuk S. Treatment of cerebral palsy children by hirudotherapy / / Mat. IV conference acc-tion girudologov M. 1995.-s. 19 
97. Kuznetsov EN Microbial flora of the oral cavity and its role in the development of pathological processes / / M-1995 
98. Kumsiashvilli JB Hirudotherapy replantirovannyh fingers / / Tbilisi - 1986 
99. Kundzinya RS, Kolenova ZD, Vilozhin AI reaction periodontitis to fill the root canal filling materials in different / / Dentistry. 1993. - № 1.-P4-7. 
100. Kunin A. A. Semenko YF, Bykov EG and other methods and results of treatment of chronic periodontitis / / High-Tech in medical diagnosis. Voronezh. 1994. - S. 101-104. 
101. Kuryakin V. Treatment destructive forms of chronic apical periodontitis with the use of Apitherapy: Author. dis. Cand. med. science.-M., 1998. 15. 
102. Kuryakin V. Treatment of chronic destructive forms of apical periodontitis with the use of Apitherapy / / M. 1998. 
103. Kuryakina NV, Kuryakin VV Apitherapy apical periodontitis / / Dentistry. 1996. - Spec. Vol. - P.63-64. 
104. Kuchta SI Haba OP, Kuchta OM Method zaverhushechnoy therapy of periodontitis in the presence of a fistula / / Dentistry. Kiev, 1989.-P.22-Vyp.24.-23. 
105. Kucherskaya Hirudotherapy VM and the system of hemostasis / / Asklepeyon № 1-4, 1995 .- with. 64-67 
106. Lebedev SA, Silolyanko LE, Trofimov VV, et al Immobilized proteolytic enzymes in clinical endodontics / / Act. Vopr. endodontics. Moscow, 1990. - P.51-55. 
107. Leonov LE Clinical and morphological study of the patency of the root canals of teeth with apical periodontitis / / Act. Vopr. endodontics. M, 1990. - p.55-59. 
108. Lakin BF Biometrics / / Moscow High School, 1989 343 sec. 
109. Leonov LE, Sirotina TL ZP Zaitseva active periodontal therapy zaapikalnaya / / VI National Conference of dentists: Dental caries and its complications. - Izhevsk, 1988 .- p.58-60. 
110. Litvintseva OR, Zhurkina EI Kiryukhina SA Application kollagenosoderzhaschey paste when filling canals with chronic periodontitis / / prevention and treatment clinics work on a new stage adjustment. Moscow, 1988. - p.96-98. 
111. Likhota TV, Fall NI Anti-anaerobic infections of periodontitis / / Dentistry, 1986, № 1,. 22-25 
112. Lukinykh LM Lifshitz N. Apical periodontitis / / Nizhny Novgorod .- 1999. 
113. Lysov A. Treatment of chronic apical periodontitis with the use of a preparation containing hydroxyapatite (clinical and experimental research): Abstract. dis.. PhD . мед. наук. -Краснодар, 1988. 19 с. 
114. Лысова М.М. Лечение хронического верхушечного периодонтита с использованием триклозана в эксперименте и клинике // Автореф. дисс . к.м.н., Ставрополь, 2001 
115. Максимова О.П., Шеина Н.М. Временное пломбирование корневых каналов // Современные технологии в стоматологии. Смоленск, 1998.-С.51-52. 
116. Максимова О.П., Петлев С.А. Клинические размышления о биологических основах и путях развития эндодонтии сегодня // Клин, стоматология №3, 2002.-е. 22 
117. Максимовский Ю.М. Патогенетическое лечение хронического верхушечного периодонтита // Стоматология. 1996. - Спец. вып. - С.67-68. 
118 . Максимовский Ю.М. Как оценить успех или неудачу в планируемом эндодонтитческом лечении // Клиническая стоматология. -1997. № 3. - С.4-7. 
119. Максимовский Ю.М. Воспаление периодонтита // Учебник по терапевтической стоматологии. М ., 1998. - С.309. 
120. Максимовский Ю.М. Сравнительная оценка антимикробного действия некоторых антисептиков, применяемых при обработке корневых каналов // Клиническая стоматология. —1997. № 3. — С.8. 
121. Максимовский Ю.М ., Митронин А.В., Ульянова Т.В., Чиркова Т.Д. Лечение периодонтита // М., 1997.- 23с. 
122. Максимовский Ю.М., Зеленина Т.Г., Воложин А.И. Экспериментальное обоснование и клиническое применение паст, содержащих лизоцим и кальцитонин для лечения хронического периодонтита // Стоматология. 1986. - Т.65. - №.3. - С.26-28. 
123. Митронин А.В. лечение хронических форм периодонтита с применением иммуномодуляторов: Автореф. дис. . канд мелд. наук.-М., 1988.-19 с. 
124. Немсадзе О.Д. Структура и чувствительность к антибиотикам возбудителей одонтогенных гнойно-воспалительных заболеваний и рациональная терапия патологических процессов // Акт. вопр. клин, микробиол. в инфекц. клинике. -М., 1988. -4.2. -С. 105-106. 
125. Николаев А.И. Критерии качества эндодонтического лечения // Современные технологии в стоматологии. Смоленск, 1988. - С.44-46. 
126. Никонов Г.И., Баскова И.П. Физиологические и биохимические аспекты лечебного действия медицинских пиявок // Успехи современной биологии, 1986. том 101, вып. 1.- с. 141-154 
127. Никонов Г.И. Фармакологические аспекты применения биологически активных соединений, продуцируемых медицинскими пиявками // Асклепейон № 1-4,1995.- с. 31-34 
128. Никонов Г.И., Гилева О.С., Живогляд Р.Н. , Кованова Э.К. Гирудотерапия и гирудофармкотерапия // М.- 1996,- с. 176 
129. Овруцкий Г.Д., Зарипова С.Ш. Особенности профилактитки и лечения обострений верхушечного периодонтита // Межтерриториальная науч.-практ. конф. курортных стоматологов. -Кисловодск. 1990. С.49-50. 
130. Овруцкий Г.Д., Кривонос С.М. Эндоканальное введение иммуномодулирующих препаратов при лечении хронического верхушечного периодонтита// Акт. вопр. эндодонтии: Тр. ЦНИИС. -М ., 1990.-С.71-74. 
131. Овчинникова И.А. Оценка эффективности комбинации антибактериальных препаратов в лечении периодонтита (экспериментально-клиническое исследование): Автореф. дис. . канд мед. наук. — М., 1998.- 22с. 
132. Олейник И.И. Микробиология и иммунология полости рта // В кн. биология полости рта. — М., 1990. — С.48. 
133. Панкратов А.С. Лечение больных с переломами нижней челюсти с использованием Остим -100 (гидроксиапатита ультравысокой дисперсности) как стимулятора репаративного остеогенеза: Автореф. дис. канд. мед. наук. М., 1995. - 19 с. 
134. Панкратов А.С., Зуев В.П., Алексеева А.Н. Применение гидроксиапатита ультравысокой дисперсности в комплексном лечении больных с переломами нижней челюсти // Стоматология. -1994.-№4.-С.22. 
135. Панкратов А.С., Зуев В.П., Иванов Н.Г.} Черноусое А .Д. Изучение иммунотропной и аллергенной активности гидроксиапатита ультравысокой дисперсности // Стоматология. — 1994.-№3.-С.37. 
136. Пашаев К.П. О значении степени обтурации корневых каналов зубов при эндодонтическом лечении // Акт. вопросы эндодонтии . М., 1990. -С.74-78. 
137. Перова М.Д., Петросян Э.А. Банченко Г.В. Гипохорит натрия и его использование в стоматологии // Стоматология. 1989. - № 2. -С .84-87. 
138. Петрикас А.Ж. Эндодонтические аспекты морфологии верхних постоянных зубов // Клиническая стоматология. 1997. -№ 2. - С.20-22. 
139. Петрикас А.Ж., Эхте А.А. О «непроходимости» корневых каналов // Современные технологии в стоматологии. Смоленск, 1998.-С.48-50. 
140. Пигаревский В.Е., Мазинг Ю.А. К методике применения лизосомально-катионного теста в лабораторно-диагностической практике // Лабораторное дело, 1981, № 10.- с. 579-582 
141. Платонов А.Е. Статистический анализ в медицине и биологии: задачи, терминология, логика, компьютерные методы // М., издательство РАМН.- 2000 
142. Позняк - Чучман В.В. Повышение эффективности диагностики прогнозирования результатов лечения хронического периодонтита с использованием пленочно-цифровой рентгенографии// Автореф. Дисс. к.м.н.- 2002.-С-П6. -20с. 
143. Пожарицкая М.М., Макарова О.В. Секреция и физиологические функции смешанной слюны в норме // М., ВУНЦ 1996 - с. 17 
144. Пожарицкая М.М., Зидра С.И. Методы традиционной медицины и перспективы применения в стоматологической практике // Новое в стоматологии, спец. выпуск 1,1994.- с. 11 
145. Полетаева Е.А. Сравнительная оценка методов лечения хронического периодонтита// Автореф. дисс . к.м.н., М.- 2000 
146. Попова Т.Г. Применение биокерамики для восстановления протезного ложа при лечении заболеваний пародонта // Автореф. дис. . канд. мед. наук. М.-1999. 
147. Посметная Т.В., Романовская Л.Д., Рупасова Н.В. и др. Некоторые особенности лечения хронических периодонтитов в стадии обострения // Актуальные вопросы теории и практики медицины. -Ульяновск, 1995. -С. 128-130. 
148. Приемская М.Г., Приемский В.Е., Пиекалнитс З.В. и др . Опыт лечения верхушечного периодонтита бакелитовой пастой // Распространенность основных стоматологических заболеваний населения Калининской области. Калинин, 1989. - С. 140-143. 
149. Прудникова О.В., Максимовский Ю.М. Бактериологические ферменты и их применение в стоматологии // Новое в стоматологии. 1996. -№ 2. - С.9-12. 
150. Пулатова Н.А. Применение гидроксиапатитсодержащих коллагеновых композиций в комплексном лечении пародонтита. Автореф. дис. канд. мед. наук. М.- 1996. 
151. Романовская Л.Д., Скуридин П.И., Журавлева Н.П. и др. Использование новых препаратов при лечении периодонтита в зубах с частично проходимыми каналами // Актуальные вопросы современной стоматлогии: Тез. докл. — Самара, 1995. — С .35-36. 
152. Русак Е.И., Дженда Е.Н., Емельянова Г.В. Опыт лечения периодонтитов новой канифоль-новоиманиновой пастой (КПП) // Организация, профилактика и реабилитация в стоматологии. Минск, 1987.- Ч.2.-С.88-89. 
153. Рыбаков А.И., Иванов BC Клиника терапевтической стоматологии. М., 1980. - 198 с. 
154. Рыбаков А.И., Иванов BC Клиника терапевтической стоматологии Н Руководство для врачей. М., 1980.- С. 142. 
155. Сабанцев Е.Г. Лечение пародонтита с применением биогенных материалов (Экспериментально-клиническое исследование): Дис. . канд. мед. наук. М., 1993. - 144 с. 
156. Савинова Е.А. Лечение хронических периодонтитов несформированных постоянных зубов у детей // Автореф. дисс .к.м.н., М.-1999 
157. Северин А.И., Кудрявцева А.И., Кулаков И.С . Ферменты бактериологического комплекса лизоамидазы // Прикладная биохимия и микробиология. 1992. - Т.28, № 5. - с.666-673. 
158. Серов В.В., Пауков BC Воспаление. М., Медицина, 1995.640с. 
159 . Сидельникова Л.В., Косенко С.В., Мехнакова Э.А. Применение математического модифицирования и прогнозирования для оценки эффективности лечения периодонтита // Стоматология. 1989. - № 4. - С.20-22. 
160. Симакова Т. Г. Клиника, патогенетическое обоснование применения гирудотерапии и фитопрепарата «Гингитек» в комплексном лечении пародонтита // Автореферат дисс. к.м.н.- 2001. 
161. Смолянко Л.Е., Трофимова В.В. Зеленина Т.Г. Результаты клинического применеия силимин-коллагеновои пасты при лечении деструктивных форм периодонтитов // Вопросы стоматологии. Иркутск, 1994. - Т.П. - С.66-67. 
162. Соловьева AM, Серый С.В. Клинико-лабораторное обоснование сочетанного применения тимогена и гидрокортизона при консервативном лечении хронического периодонтита // Актуальные вопросы эндодонтии. -М., 1990. С.83-86. 
163. Соснин Г.П., Астапенко Я.П., Даревский В.И. Отдаленные результаты применения мефенаминовой пасты при лечение осложнений кариеса//Актуальные вопросы эндодонтии. М., 1990. -С.86-88. 
164. Суслова С.И., Воробьев BC, Дедеян С.А. и др. Результаты клинического применения пасты, содержащей коллаген, для пломбирования корневых каналов зубов // Стоматология. 1985. -№2.- С.24-25. 
165. Тарасенко JI.M., Скрыпник И.Н., Непорада А.С. Параллелизм метаболических нарушений в тканях желудка и пародонта при стрессорных воздействиях / / Бюлл. эксп. биологии и медицины, 2000, № 7.- с. 31-34 
166. Татаренко JI.JI. Гонтарь Е.А. Лечение периодонтитов с применением фузидина и димексида // Актуальные вопросы эндодонтии. -М., 190 . С.91-93. 
167. Троицкая В.Н., Новикова В.А. Некоторые аспекты лечения осложнений кариеса // Актуальные проблемы стоматологии. Смоленск, 1997. - С.52-54. 
168. Уразапина Е.А. Лечение хронического периодонтита с применением биогенной пасты на основе хондроинтинсульфата // Экспериментальные и клинические проблемы в стоматологии. Алма-Ата, 1989.-С.14-18. 
169. Ушаков Р.В., Царев В.Н. Этиология и этиотропная терапия неспецифических инфекций в стоматологии // Иркутск, 1997.- 110 с. 
170. Франке Ю., Рунге Г. Остеопороз // Москва, Медицина, 1995.299с. 
171. Фролова О.А., Исакова В.И. Лечебный эффект биогенной пасты при экспериментальном хроническом периодонте // Стоматология. 1990. -Т.69, № 1. - С.20-22. 
172. Хазанова В.В., Земская Е.В., Дмитриева Н.А. и др. Сравнительная оценка антимикробного действия некоторых антисептиков, применяемых при обработке каналов // Клиническая стоматология. 1997. -№ 3. - С.8-11. 
173. Хазанова В.В., Земская Е.А., Дмитриева Н.А., Жохова Н.С. Влияние местного применения комплекса антибактериальных препаратов натечение хронического периодонтита // Клиническая стоматология. 1977. - № З.-С. 12.
174. Khaitov PM, Pinegin BV, Eastham HI Ecological immunology / / VNIIRO.-1995 
175. Khamrayev TK The use of hydroxyapatite ceramic granules for replacement of defects of the jaw bone (experimental clinical research) / / Abstract. Dis. . cand. med. Science. Moscow, 1994. -23 Sec. 
176. Hamsters JN Natural and synthetic anticoagulants and their use for the regulation of cellular activity / / Abstract. diss. Dr.-2001 
177. Chilikin VN Keys to the success of endodontically / / Klin, Dentistry № 3,2002 .- with. 28-30 
178. Chukaeva NA Choice of treatment of patients with acute and exacerbated periodontitis based on clinical and immunological parameters / / Abstract. Dis. cand. med. Science. Moscow, 1990.-19. 
179. Chuchmai GS, Tsvyh JI.A., Focsa RJ etc. The effectiveness of treatment of chronic periodontitis with antibacterial drugs and ntioksidantami / / Actual questions of endodontics. -M, 1990 .- S. 103-106. 
180. Shaydullina HM, Zaripov, NR, Karpov, MG Experience in treatment of acute exacerbations of chronic periodonita / / Organization of dental services and dental training of personnel in the republic of Bashkortostan. , Ufa, 1996.-4.1-p.41-42. 
181. Shargorodsky AG Bazhanov NN, Gubin MA and other health interventions in dental surgery / / Stomatologiya.-1990 .- № 6.-p.81-84. 
182. Shargorodsky AG Inflammatory diseases of the tissues of the maxillofacial area and neck / / M. GOU VUNMTS MZRF .- 2001 
183. Sheina, NM, Grigorieva EV How to quickly and correctly apply the cofferdam / / Klin, dentistry № 3,2002 .- with. 10 
184. A. Shumsky Lymphotropic, drug and immunocorrective therapy in complex treatment of infectious and inflammatory diseases of the oral mucosa / / Abstract. diss. MD - 1998.-30c. 
185. Ehte AA Duration of activity of some antimicrobial drugs in root canals of teeth in the treatment of apical periodontitis / / Actual questions of endodontics. Moscow, 1990.-C.111-114. 
186. Jansson KA, Saulgozis YU.ZH. Implantation of the achievements and prospects / / Journal of the All-Union Chemical Society myocardial infarction Mendeleev. - 1985. - T.ZO. - S.428. 
187. Adriaens PA, Edwards С.A., De Boever JA et al. Ultrastructural observation on the bacterial invasion of cementum and radicular dentin of periodontaliy diseased teeth / / J. Periodontal. 1988. - Vol. 59, N 6. -P. 493-503. 
188. Albe, T., Hara Y., Abe Y. et al. Serum or growth factor deprivation induces the expression of alkaline phosphatase in human gingival fibroplasts / / J. Dent. Res. 1998. - Vol. 77, N 9. - P. 1700-1707. 
189. Albers HK Tierexperimontelle Untersuchungen zur Behandlung non parodontalen Knochentaschen mit Hilfe von Hydroxylapatitkeramik. ZWR. 1990. - Sep. VoL 99, N. 9. - P. 714-718, 720-721. 
190. Amano Y., Shimomura I, Tsumoda Y. et al. A study on condensability in lateral condensation technique of root canal filling / / Jap. J. Conserv. Dent. 1995. - Vol. 38. - P. 57-58. 
191. Ando N., Hoshino E. Predominant obligate anaerobes invading the deep layers of root canal dentine / / Int. Endodontic J. 1990. - Vol. 23, N. l.-P. 2027. 
192. Avora RK, Gulabilava K. An in vivo evaluation of the ENDEX and RCM Mark II electronic apex locators in root canals with different contents / / Oral Surg. 1995. - Vol. 79, N 4. - P. 497-501. 
193. Barbosa SV, Spanberg LSW, Almeda D. Calcium hydrochloride solution with low superficial tension an effective antiseptic / / Int. Endodontic J. -1994.-Vol. 27, N. l.-P. 6-10. 
194. Barkhordar RA, Dsoula XG Sealing ability of calcium sealers / / Oral Surg. 1988. - Vol. 65, N. 6. - P.763-767. 
195. Barkhordar RA, Stark MM, Soelberg K. Evaluation of the apical sealing ability of apatite root canal sealer / / Quint. Intern. 1992. -Vol. 23, N.7.-P.517-518. 
196. Bell R., Beirne OR Effect of hydroxylapatite, tricalcium phospate and collagen on the healing of defects in the rat manible / / J. Oral Maxillofac Surg. 1988. - Vol. 46, N. 7. - P.589-594. 
197. Bentley EM The value of ultrasonic cleaners in dental practice / / Brit. Dent. J. 1994 .- Vol. 177, N 2. - P.53-56. 
198. Bergenholtz G. Microorganisms from necrotic pulps of traumatized tooth / / Odontologisk. Revy.1974. - Vol. 25, N 3. -P.347-349. 
199. Bonfil JJ, Tavitian P., Bertrand G. et al. Study of behaviour and endurance of Bioapatite ® implanted in the periodontium of the dog: (closed model) / / Bull. Group. Int. Rech. Sci. Stomatol. Odontal. 1995 /-Vol. 39, N / 2. -P.7-16. 
200. Bruno E., Paini L., Giardini R. Sovrariempimento canalare: Reazioni immunitarie periapicalli / / Minerva stomatol. -1995. Vol. 44, N10.-P.439-444. 
201. Bystrom A., Sundqvist G. Bacteriologic evaluation of the effect of 0.5 percent sodium hypochlorite in endodontic therapy / / Oral Sur. -1983. Vol. 55, N 8. - P.307-312. 
202. Bystrom A., Sundqvist G. Bacteriologic evaluation of the efficiency of mechanical root canal instrumentation in endodontic therapy / / Scand. J. Dent. Res. -1981. Vol. 89, N 8. -P.321-328. 
203. Butler TK, Crawford JJ The detoxifying of varying concetrations of sodium hypocholite on endotoxins / / J. Endodont. -1982.-Vol. 8, Nl.-P.59-66. 
204. Caliskan MK Long-term result of treating periapical lesions of mature non-vital teeth by calcium hydroxide / / Int. Endodontic J. 1994. -Vol. 27.-P.94-11. 
205. Chong BS, Owadally Jd, Pitt-Ford TR et al. Antibacterial activity of potential retrograde root filling materials / / Endod. Dent. Traumatol. 1994. -Vol. 10, N 2. - P.66-70. 
206. Coveiello JA Dynamic approach to oral implantology / / J. clin. Periodont. 1980. - Vol. 7, N 3. - P.224-235. 
207. Dalat D., Spanberg ESW Comparison of root canal obturation techniques using a dye vacuum tracing method / / Int. Endodontic J. -1994 .- Vol. 24.-p.94-l 11. 
208. Drobock HP Hydroxylapatite un material de substitution de L'os par excellence / / Chir. dent. Fr.1989. - Vol.59. 476. - P.39-44. 
209. Dudin AB, Demina TA, Loos LP Hirudotherapy in the treatment of oral mucosal lesious / / The 2nd Asia Pacific Workshop for Oral Mucosae Lesious Chiang-Mai, Thailand, 1995, p. 36 
210. Dumsha JL Cleaning and shaping the root canal system. Pathways of the pulp.; St. Louis, 1987. 346 p. 
211. Edwardsson S. Bacteriological studies on deep areas of carious dentin / / Odontal. Revy. 1974. - Vol. 25, N 1. - Pl-143. 
212. Feidmann H. True and artificial leeches and their use in otology / / Laryngorhinootologie, 1994-Vol.10, p. 551-555 
213. Ferraro JW Experimental evaluation of ceramic calcium phosphate as a substitute for bone graft / / Plast. Reconst. Surg. Vol. 63, N5.-P. 634-637. 
214. Fonad AF Il-la and TNF-L expression in early periapical lesions of normal and immunodeficient mice / / J. Dent. Res. 1997. - Vol. 76, N 9/.-P.1548-1554. 
215. Fukase Y., S. Wada, H. Uehara et. al. Evaluation of molding and handling properties of hydroxyapatite paste / / J. Dent. Res. 1998. -Vol. 11, Suppl. Issue A. - P.242. 
216. Gao J., Symons AL, Bartold PM Expression of transforming growth factor beta 1 (TGF-(31) in the developing periodontium of rats / / J. Dent. Res. - 1988. - Vol. 77, N9. - P. 1708 -1716. 
217. Gilbert BO, Rice RT Re-treatment in endodontics / / Oral. surg. -1987. Vol. 64, N 3. - P.333-338. 
218. Ginebra MP, Fernandez E., Maeyer EAP et . al. Setting reaction and hardening of an apatitic calcium phosphate cement / / J.Dent.Res. -1997. Vol. 76, N4. - P.905-912. 
219. Glonti N. Stimulation of periapical reparation with "CRCS" -root canal sealer / / Proceedings of the International Congress of Dentists (Tbilisi, 17-18 October 1997). Tbilisi, 1997. - S. 144. 
220. Gutierrez YH Scanning electron microscope study on the action of endodontics irrigants on bacteria invaliding the dental canals / / Oral Surg. 1990.-Vol. 69, N 4. - P.491-501. 
221. Gutmann JL, Lovdahl PE Problems in the assessment of success and failure, quality assurance, and their integration into endodontic treatment planning / / Problem solving in Endodontics: St. Louis. 1,997. -192 p. 
222. Hahn CL, Falker WA, Mirah GE Microbioligical studies of carious dentin from human teeth with irreversible pulpitis / / Arch. Oral Biol. -1991.-Vol. 36, N 1.-P.147-153. 
223. Happonen RP Periapical actinomykosis. A follow up study of 16 surgically treated cases / / Endod. Dental Traumatology, 1986,2:205-209 
224. Hauper R., Lutz F ., Barbakow F. An in vivo comparison of gradient and absolute impedance electronic apex locators / / J. Endod. -1996. Vol.22, N 5.-P.260-263. 
225. Hayamizu K., Yakata H., Fukuda Y. Lymphokine mediated secretion of a supressor factor by monocytic cells derived from human adult peripheral blood / / Transpl. Proceed. - 1994. - Vol. 26, N 4.-P.1866-1867. 
226. Heling I., Chandler NP The antimicrobal effect within tubules of four root canal sealers / / J. Endodont. 1996. - Vol. 22, N 3. - P.257-259. 
227. Hemmerle J, Cuisinier FJG, Schultz P. et al. HRTEM study of biological crystal growth mechanisms in the vicinity of implanted synthetic hydroxyapatite crystals / / J. Dent. Res. 1997. - Vol. 76, N 2. - P.682-687. 
228. Henriot JM, Chaillot B., Rochette L. The medicinal leech Hirudo medicinalis: clinical use of the animal and therapeutic prospects in hirudin / / J. Pharm. Belg. 1990. Vol. 45. # 3, p. 207-218 
229. Hoexter DL The use of tricalcium. Part I: its use in extensive periodontal defects / / J. Oral Implantantol. 1983. - Vol. 10, N 4.-P.534-599. 
230. Horiguchi T., Doi Y., Seung-Hyo Kirn et al. Apatite-collagen complex: Preparation of a new apatite-collagen complex / / J. Jap. Soc. Dent. Mater / A. Devices. Vol. 9, N 6. - P.863-870. 
231. Hoshino E. Predominant obligate anaerobes in human carious dentin / / J. Dent. res. 1985. - Vol. 64, N 12. - PI 195-1198. 
232. Imamura M., Magata T., Saito F. et al. The cleaning effects on the root canal by the ultrasonic device / / Jap. J. Conserv. Dent. 1989.-Vol. 32.-P.769-777. 
233. Ito K, Murai S. Root resorption associated with hydroxyapatite particles: a case report / / Quint. Intern. 1995. - Vol. 26, N 6. - P.377-383. 
234. Jarcho M. Calcium phospate ceramics as a hard tissue prosthetics / / Clin. Orthop. -1981. Vol.157, N 6. - P .259-278. 
235. Jeansonn MJ, White RR A comparison of 2.0% chlorhexidine gluconate and 5.25% sodium hypochlorite as antimicrobial endodontic irrigants / / J. Endodont. 1994. - Vol. 20, N.3. - P.276- 278. 
236. Joffe E. obturation root canal. To the top? over the top? / / new in dentistry. 1998. - R.276-278. 
237. Juhasz A., Hegedus S., Flora Nagy E. et al. Semi -quantitative, three-dimensional leakage study of three endodontic sealers / / Int. Endodontic J. - 1996.-Vol. 29.-P. 195-210. 
238. Juric H., Anic J. Kvaliteta brtvljenja korijenskoq kanala postignuta razlicitim tecnikama punjenja / / Acta stomatol. Croat. 1995. - Vol. 29, N2.-P. 105-111. 
239. Kakehashi S., Stanley HR, Fitzherald RJ. The effect of surgical exposures of dental pulp in germfree and conventional laboratory rats / / Oral Surg. Oral Med. Oral pathol. 1965. - Vol. 20, N 6. - P.340-349. 
240. Kerosuo E., Orstavik D. / Ranta K. et al. Healing of apical periodontitis assessed by computerized image analysis / / J. Dent. Res.-1998.-Vol. 77, N5.-P.1333. 
241. Khakhanashvili J., Sushitashvili D., Menabde G. et al. The main aspects of treatment of periapical pathologic processes / / Proceedings of the International Congress of Dentists (Tbilisi, 17-18 October 1997)., Tbilisi, 1997. S. 179-180. 
242. Khakhanashvili J., Lordkipanidze M. The treatment of periapical inflammory conditions through conservative method / / Max.-fac. Surg, and Stomatol. Conference of Black Sea countries. Tbilisi, 1997.-C.84-85. 
243. Kidd E. Smith B., Pickard H. Pickard 's manual of operative dentistry: EHBS.-1990. -191 p. 
244. Kimura M., Sorata Y., Yanome S. Study of root canal cements comprising calcium aluminate. First report on cytotoxicity / / Shoni shikaga zasshi. -1991. Vol. 46, N 3. - P.283 -295. 
245. Kirner A. Zubu granulon a fokalna infekcija / / Czasop. Stoma.-1986.-2.-P.150-155. 
246. Kiryu T, Hoshino E., Iwaku M. Bacteria invaliding periapical cementum / / J. Endodont. -1994. Vol.20, N 3. - P. 169-172. 
247. Kontakiotis E., Georgopoulou M., Panopoulos P. et al. In vitro study of the antibacterial properties of two calcium hydroxide- based root canal sealers / / Int. Endodontic. J. 1996. - Vol.26, N 3. - P. 195-210. 
248. Kontakiotis E., Nalopoulou H., Georgopolou H. In vitro study of indirect action of calcium hydroxide on anaerobic flora of the root canal / / Int. Endodontic J. 1995. - Vol.28, N 3. - P.285-289. 
249. Kornman KS, Karl EH The effect of long term low dose tetracycline therapy on the subgingival microflora in refractory adult periodontitis / / J. Periodontol. 1982. - Vol.53, N 8. - P.604-610. 
250. Krammer J., Schlepper H. endodontic instruments company user VDW (translated from German). M ., 1996. 
251. Kubes P., Payne D., Woodman RC Molecular mechanisms of leukocyte recruiment in post icshemic liver microcirculation / / Eng. J. Physiol. Gastrointest. Liver Physiol., 2002. m-283 (1). G 139-47 
252. Lamster IB, Smith QT, Celenti RS development of a risk profile for periodontal disease: microbial and host response factors / / J. Periodontol. -1994. Vol.65, N 5. - P.511-520. 
253. Levin MP, Getter L., Cutright DE A comparison of iliac narrow and biodegradable ceramic in periodontal defects / / J. Biomod. Mat. Res.-1975.-N9.-P.183-187. 
254. Mackie IC, Worthington HV, Hill FY A follow-up study of incisor teeth which had been treated by apical closure and root filling / / Brit. Dent. J. -1993. Vol.175, N 1. - P.99-101. 
255. Madison S., Anderson RW Medications and temporaries in endodontic treatment / / Dent. Clin. North Amer. 1992. - Vol.36, N 3.-P.343-356. 
256. Malagnino VA, Gambarini GL, Tirafili C. Fenomenu immunitari nelle lesioni pulpo-periapicali / / Minerva Stomatol. 1992.-Vol.41, Nll.-P.483-489. 
257. Mckay GS The histology and microbiology of acute occlusal dentine lesions in human permanent molar teeth / / Arch. Oral Biol.-1976.-Vol.21, N1.-P.51-58. 
258. Meredith N., Gulabivala K. Electrical impedance measurements of root canal length / / Endod. dent., Traumatol. 1997. - Vol.13 , N 3.-P.126-131. 
259. Mellonig JT Porous particulate hydroxyapatite in a human periodontal osseous defect: a case report / / Intern. J. Perdontics And Restorative Dentistry. 1990. - Vol.11, N 3. - p.216-223. 
260. Minabe M, Takenehi K., Kumada H. The effect of root conditioning with minocycline HCI in removing endotoxin from the roots of periodontally-involved teeth / / J. Periodontol. 1994. - Vol.65, N5.-P.387-392.
261. Molander A., Reit C., Dahlen G. et al. Microbiological examination of root filled teeth with apical periodontics / / Int. Endodontic J. 1994. - Vol.27, N 6 .-P.94-111. 
262. Morse DR Immunologic aspects of pulpalperiapical diseases. A review / / Oral Surg. 1977. - Vol.43, N 3. - P.436-451. 
263. Mors WA, Kaminski EJ Osteogenic replacement of tricalcium phosphate ceramic implants in the dog palate / / Arch. Oral Biol. 1975.-N20.-P.365-374. 
264. Naidorf IL Inflammation and infection of pulp and periapical tissues / / Oral Surg. 1972. - Vol .34, N 3. - P.486-497. 
265. Negm MM Effect of intracanal use of non-steroid anti-inflammotcry agents on posttreatment endodontic pain / / Oral. Surg. -1994. Vol. 77, N 5. - P.507-513. 
266. Nery EB, Legeros RZ, Lynch KE, Lee K. Tissue respons to biphasic calcium phosphate ceramic with different ratios of HA / beta TCP in periodontal osseous defects / / J. Periodontal. 1992. - Vol. 63, N 9.-P.729-735.115 
267. Nery EB, Lynch KL, Rooney GE Alveolar ridge augmentation with tricalcium phosphate ceramic / / J. Prothet. Dent. 1978. - Vol.40. -P/668-673. 
268. Oksala O., Haapasalmi K., Hakkinen H. et al. Expression of heparin sulphate and small dermatan / chondroitin sulphate proteoglycans in chronically inflamed human periodontum / / J. Dent. Res. 1997.-Vot.76, N 6. -P. 1250-1259. 
269. Orstavik D., Kerekes K., Eriksen HM The periapical index: a scoring system for radiographic assessement of apical periodontitis / / Endodontics in Dental Traumatology 2:20-34, 1986 
270. Orstavik D. , Haapsalo M. Disinfection by endodontic irrigants and dressings of experimentally infected dentinal tubules / / Endodont. Dent. Traumatol. 1990. Vol.6, N 4. - P. 142-149. 
271. Peltis GJ, Koban EB Tissue response to composite ceramic hydroxylapatite / / Med. priority J. 1990. - N 12. - P.732. 
272. Pilot TF, Pitts DH Determination of impedance charges at varying frequencies in relation to root canal file position and irrigant / / J. Endod. 1997 .-Vol.23, N12.-P.719-724. 
273. Puiver WH, Taubman MA, Smith DJ Immune components in human dental periapical lesions / / Arch. Oral Biol. 1978. - Vol.23, N 6 .- P.435443 
274. Rutanto F., Ricucci Ds Gulla R. Un nuovo cemento caricato con idrossilapatite. Risultati clinic preliminary / / Dent. Cadmos. 1990.-Vol.58, N8.-P.108-114. 
275. Safavi E ., Spanbergl L., Hangeland K. Root canal dentinal tubule disinfection / / J. Endodont. 1990. - Vol 16, N 4. - P.207-210. 
276. SchefFer P., Ouazzani A. Esteban J. et al . Infection graves cervicofacial d'origine dentaire / / Rev. Stomat Chir. maxillofac.-1989.-Vol.90, 3.-P.115-118. 
277. Seymour RA, Heasman PA Tetracyclines in the management of periodontal diseases. A review / / J. Clin. Periodontol. 1995. - Vol.22, Nl.-P.22-35. 
278. Shalhav M., Fuss Z., Weiss E. Antimicrobal activity of calcium hydroxide containing endodontic sealers on streptococcus faccalis in vitro / / Int. Endodontic J. - 1996. Vol.29. - P. 195-210. 
279. Siqueira JK, Concalves RB Antibacterial activities of root canal sealers against selected anaerobic bacteria / / J. Endodont. 1996.-Vol. 22, N1.-P.79-80. 
280. Sobarzo-Navarro M. Clinical experience in root canal obturation by thermoplasticized injectable gutta perch technique / / J. Endod. -1991. Vol.17, N 8. - P.389 -391.